… interest in locking the S trimer into the prefusion conformation. … the prefusion conformation
of the SARS-CoV and MERS-CoV … did not appear to inhibit RBD motion in SARS-CoV-2 (24), …

… conformation of the native monomer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
monomeric M pro , and locks the monomeric M pro in the extended conformation. …

… The NTD and RBD are better resolved in the cryo-EM density in the locked conformation
than in the closed conformation (Extended Data Fig. 2a), suggesting they are less mobile in this …

… We superimposed our LA-bound structure on previous SARS-CoV-2 apo S structures in
the closed conformation (7, 17) and identified a gating helix located directly at the entrance of …

… The structure of the FFA (in cyan) has been superimposed onto our results as it was shown
to lock the closed state by forming contacts between two adjacent RBDs. Panel (D) depicts …

… site, revealed a compact, locked S conformation adopted by ~70% of … In agreement, differences
between different β-coronavirus … RBD conformations with repercussions on SARS-CoV-2 …

… characterize the conformational fluctuations and interdomain interactions of SARS-CoV-2 …
The interdomain hydrogen-bond and glycan interactions are rearranged in the conformational …

… ), S2 domain, and stalk domain of S protein conformations at various pH values. Several key
… conformation. This study will assist in developing novel therapeutic measures against SARS…

… switching between conformational states of the SARS-CoV-2 … the conformational and dynamic
changes in the SARS-CoV-… of the SARS-CoV-2 spike (S) protein trimer in the locked and …

… a heterogeneous, length-dependent conformational landscape consisting of an assumed
3-… , reveal interconvertible L and linear conformations likely related to ribosomal pausing and …