… studies using locked nucleic acids … conformational heterogeneity of five stem-loop elements,
ranging in size between 17 and 44 nucleotides, located at the 5′-UTR in the SARS-CoV-2 …

… of SARS-CoV-2 RBD by ACE2. Our findings depict the mechanism of ACE2-induced S trimer
conformational … , facilitating development of anti–SARS-CoV-2 vaccines and therapeutics. …

… Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab … SARS-CoV-2 from
binding to the ACE2 receptor. Binding of the antibody also restrains any further conformational …

… in a locked conformation. According to this model, their replacement (perhaps with asparagine)
would remove the pH-dependent destabilisation of locked spike trimer conformations, …

… incompetent conformation and that many of the key interactions of the active conformation
of … This novel conformation is relevant both for comprehension of the mechanism of action of …

… The overall architecture of the SARS-CoV-2 S2 in the postfusion conformation is nearly …
-S2' fragment makes up three helical regions locked by two disulfide bonds that pack against the …

… We hypothesize that the Phe140-His163 π-π interaction (with an average distance of ∼4.1
Å, Figure 5I ) would be relevant to lock His163 in a hydrogen bond prone conformation. …

… However, when His172 is charged, it forms a salt bridge with Glu166, which locks Glu166 in
… SARS-CoV Mpro, our data provides a detailed molecular mechanism of the conformational …

… the SARS-CoV-2 Spike Protein spanned by two conformational coordinates. In this study,
each continuous conformational … A conformational coordinate consists of a space of 50 binned …

… -CoV-2 spike protein … the conformational flexibility and energetic frustration at the interprotomer
interfaces may serve as an efficient mechanism for allosteric regulation of the SARS-CoV-…