… their protonation/deprotonation modulates catalysis and conformational plasticity. Here,
we … conformational dynamics of SARS-CoV-2 in comparison to SARS-CoV and MERS-CoV …

… Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab … SARS-CoV-2 from
binding to ACE2 receptor. Binding of the antibody also restrains any further conformational …

… Stapled peptides are a novel therapeutic modality that allows locking a structure in its
bioactive conformation through the site-specific introduction of a chemical linker. (34−36) These …

… approach for adequate simulation of conformational dynamics of the SARS-CoV-2 S trimers
with … S2M11 functions by locking down the SARS-CoV-2 S trimer in the closed state through …

… first contact point between the SARS-CoV-2 virus and host … receptor, stabilizing a locked
conformation of the protein. Here… a significantly different conformational response for some …

… locked conformation is assumed by spikes of animal CoVs closely related to SARS-CoV-2:
RaTG13 bat-CoV [… Qu et al. recently showed that disulphide-stabilised SARS-CoV-2 spike can …

… This study reported that linoleic acid (LA) binding to a distal site of the RBM locks the
SARS-CoV-2 spike trimer in a closed conformation, which is incompatible with ACE2-receptor …

… Our aim was to study the conformational dynamics of the SARS-CoV-2 RBD, as well as
that of several other SARS-CoV-2 VOCs in solution. To this effect, we simulated the wt, Alpha, …

… it has been suggested to lock the closed pre-fusion spike protein conformation and therefore
… nAb class than the one elicited by natural SARS-CoV-2 infection and suggests the design of …

… , it remains that the compact FPPR conformation has been reported under an open RBD,
casting doubt on the hypothesis that a compact FPPR conformation locks the RBD in a closed …