… of SARS-CoV-2 spike trimer in the closed and open states. A. The closed conformation of
SARS-CoV… of the RBD-ACE-2 complex through locking residues K353 and Y41 (ΔG mut /ΔG wt …

… structures, except for the ‘locked’ conformation, where it is notably stabilized with three
RBD Down forms [10,11]. In the resolved structures of the ‘locked’ conformation, the 833–855 …

… into the structural conformation of the SARS-CoV-2 spike, … We highlight the different mAb
epitopes on SARS-CoV-2 S … This suggests that 2–43 can lock the spike in a closed conformation…

The 3C-like protease of SARS coronavirus (SARS-CoV 3CL pro ) is vital for SARS-CoV … of
these two residues in maintaining the active conformation of SARS-CoV 3CL pro . S139A is a …

The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need
for highly effective vaccine candidates that are thermostable and amenable to large-scale …

… and use it for microsecond-scale MD simulations to characterize its conformational dynamics.
We describe these conformational changes in terms of bending and twisting motions of the …

… domain (RBD) causing conformational changes in S protein … Unraveling the dynamic
structural features used by SARS-CoV-2 … conformational states adopted by the SARS-CoV-2-RBD. …

… proteins and complexes that pertain to SARS-CoV-2. Together, … of conformational changes
that are essential for SARS-CoV-2’… SARS-CoV-1 has the highest population of conformations …

… structure of CoV-2-S is basically identical to that of SARSCoV and MERS-CoV Spikes, however
CoV-2… In the down conformation, CoV-2-S cannot mediate CoV-2 fusion with the host cell …

… binding to the ACE2 binding site or by locking the RBD in a receptor-inaccessible down …
effectively stabilized the MERS-CoV and SARS-CoV spikes in the prefusion conformation [39,40]…