… In our analysis, all BriSΔ particles exhibited the locked conformation of the S trimer we
had described previously 23 . After applying 3-fold symmetry (C3) we obtained a 2.8 Å cryo-EM …

… BUDE docks linoleate into the locked SARS-CoV-2 spike trimer in a conformation
consistent with cryo-EM structures. A) Cryo-EM structure of the LA − -bound spike trimer in the …

… ACE2 binding but also alter the Spike protein conformational cycle triggered by ACE2
binding. We show that stabilization of different Spike conformations leads to modulation of Spike-…

… pro (M pro C) locks M pro into a hyperactive … conformations by mutations or ligand binding.
Finally, because all residues in the tryptophan loop are identical in SARS-CoV and SARS-CoV…

We modeled 3D structures of all SARS‐CoV‐2 proteins, generating 2,060 models that span
69% of the viral proteome and provide details not available elsewhere. We found that 6% of …

… Taken together, this shows that of all of the conformations tested, only the trimeric form of
SARS-CoV-2 FP-L is capable of triggering the formation of a fusion bridge between dual …

… highly dynamic loop in the SARS-CoV-2 spike protein RBM from residue 475 to 485. It is
predicted by induced fit theory 39 that the binding event induces a conformational change at the …

… structures it is locked in one place by crystal lattice contacts. … a set of water-refined
conformations for the protein:dsRNA … it was selected as a representative conformation for the …

… In addition, further stabilization of the prefusion conformation of spike might improve … (S-locked),
in which the receptor binding domains (RBDs) were locked in a closed conformation and …

… syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus …
containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the …