Importance Recent studies have reported an increase in the number of fetuses and
neonates with microcephaly whose mothers were infected with the Zika virus (ZIKV) during
pregnancy. To our knowledge, most reports to date have focused on select aspects of the
maternal or fetal infection and fetal effects. Objective To describe the prenatal evolution and
perinatal outcomes of 11 neonates who had developmental abnormalities and neurological
damage associated with ZIKV infection in Brazil. Design, Setting, and Participants We …

To the EditorIn their timely description on the major central nervous system lesions caused
by Zika virus (ZIKV) congenital infection, Melo et al1 reported on the neuroimaging,
laboratory, and histological findings among 11 children born with ZIKV congenital infection
syndrome. Aside from microcephaly and its associated cortical malformations, the authors
also described the presence of arthrogryposis among 3 children. In the pathological
findings, they observed fewer than expected motor nerve cells in the spinal cord in 1 of the …