… in the context of pulmonary fibrosis. A better understanding of … of connective tissue
remodeling in pulmonary fibrosis. … Thus, it appears that connective tissue synthesis is critical to …

… lung are quiescent, synthesizing little collagen. We studied lung biopsies from 30 patients
with pulmonary fibrosis… to localize fibroblasts actively synthesizing collagen. Adjacent sections …

… pulmonary fibrosis [63,64]. TGF-β regulates the mechanism of myofibroblast differentiation
and connective tissue … on fatty acid oxidation and synthesis or lipolysis but on glycolysis [121]. …

… rates of metabolism of the connective tissue proteins in the lung. That is, shifts in the relative
rates of synthesis and degradation leading either to excessive deposition (fibrosis) or loss of …

Introduction Fibrotic interstitial lung disease (ILD) is a frequent and severe complication of
connective tissue disease (CTD). Areas covered In this narrative review, we update the most …

The pathogenesis of fibrotic disorders is similar regardless of the tissues involved. … sustains
the connective tissue accumulation, which results in permanent alteration in tissue structure …

… of fibrous tissue is generally assumed to be an active process resulting from an increased
synthesis of connective tissue components in response to injury (13). "Fibrous tissue" is …

… In the healthy lung, this stabilising system of connective tissue allows the volume to change
… The alveolar epithelial type II cells (AE2 cells) synthesize the components of the surfactant in …

… controlled wound repair from uncontrolled connective tissue deposition, leading to
pathological fibrosis. In pulmonary fibrosis, matrix synthesis often continues despite the apparent …

… Indeed it is likely that it is continued deposition of connective tissue in tissue mechanically
distorted by cellular contraction that produces permanent tissue remodeling. Interstitial fibrosis…