[HTML][HTML] Identification of conserved epitopes in SARS-CoV-2 spike and nucleocapsid protein

S Forcelloni, A Benedetti, M Dilucca… - Current Genomics, 2021 - ncbi.nlm.nih.gov
… for conserved epitopes that might help develop broad-spectrum SARS-CoV-2 vaccines. …
We show the presence of both conserved epitopes and non-conserved epitopes in terms of rate …

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv… - Science, 2020 - science.org
… -2 and SARS-CoV. Recently, our group and others have identified a conserved epitope on
influenza A virus … to the epitope of CR3022. Antibodies to this influenza HA trimeric interface …

Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide

FF Vale, JMB Vítor, AT Marques, JM Azevedo-Pereira… - Virus Research, 2021 - Elsevier
Conserved epitopes are likely to provide broader protection across multiple virus strains,
than those … The degree of the predicted epitopes conservation was evaluated. The impact in …

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

S Jiang, S Wu, G Zhao, Y He, X Guo… - Emerging microbes & …, 2022 - Taylor & Francis
… In this study, we have defined and characterized a potential CTL epitope of the spike protein
conserved among all the SARS-CoV-2 variants and validated its capacity to elicit IFN-γ and …

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
SARS-CoV-2 strains. Structural analysis showed that SARS2-38 engaged a conserved
epitope … of neutralizing antibodies that bind conserved spike epitopes may limit the loss of …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
conserved epitopes between the two virus strains. In this study, we focus on the conserved
epitopes between SARS-CoV-2 and SARS-CoV. … (bnAbs) against SARS-CoV, SARS-CoV-2, …

Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination

ES Geanes, C LeMaster, ER Fraley, S Khanal… - Scientific Reports, 2022 - nature.com
… -conjugate vaccine with a conserved SARS-CoV-2 S2 spike epitope, immunized mice and
… binding to SARS-CoV-2 and other related coronaviruses. This conserved spike epitope also …

CD8+ T-cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

AD Redd, A Nardin, H Kared, EM Bloch… - Open Forum …, 2021 - academic.oup.com
… global SARS-CoV-2 variants that overlapped with 52 CD8+ T-cell epitopes previously …
Additionally, this mutation was found on the third residue of the epitope, and given that the …

[HTML][HTML] Coronavirus epitope prediction from highly conserved region of spike protein

V Yurina - Clinical and experimental vaccine research, 2020 - ncbi.nlm.nih.gov
… , which has been contagious in Saudi Arabia since March 2012, has never before been
found in the world and has characteristics that are different from the SARS coronavirus that …

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

D Sun, Z Sang, YJ Kim, Y Xiang, T Cohen… - Nature …, 2021 - nature.com
… II binds highly conserved epitopes and retains activity against VOCs and RBD SARS-CoV .
… In summary, Class I Nbs bind the RBS epitopes and can potently inhibit the virus by directly …