Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
cytokine patterns, it seems that the cytokine storm plays a crucial role in the pathogenesis of
COVID-19-, SARS- and MERS. Monocytes … IFN response in monocytes and macrophages. …

[HTML][HTML] Understanding the cytokine storm during COVID-19: Contribution of preexisting chronic inflammation

P Miossec - European Journal of Rheumatology, 2020 - ncbi.nlm.nih.gov
monocytes that subsequently induce the production of IL-6 … neutrophils are involved suggests
the contribution of the IL-17 … is the cytokine storm with increased levels of these cytokines in …

Role of monocytes/macrophages in Covid-19 pathogenesis: implications for therapy

J Gómez-Rial, I Rivero-Calle, A Salas… - Infection and Drug …, 2020 - Taylor & Francis
… of inflammatory monocytes infiltrating from peripheral blood, resulting in a cytokine storm
and … contribute to the development of low-grade inflammation observed in obesity. Citation50 …

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
… of cytokine levels paired with deep-immune profiling shows that classical monocytes drive
this … Furthermore, we report that neutrophils contribute to disease severity and local tissue …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… critical adults leads to a cytokine storm, which is characterized by severe systemic elevation
of several pro-inflammatory cytokines. Then, a cytokine storm can induce edematous, ARDS, …

Monocytes and macrophages in COVID-19: Friends and foes

S Meidaninikjeh, N Sabouni, HZ Marzouni, S Bengar… - Life sciences, 2021 - Elsevier
… and exacerbated reactions that contribute to the tissue damage, … monocytes can induce
acute inflammatory responses through exerting inappropriate activity and cause cytokine storm

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been … Cytokine storms (CSs) are associated
with various pathologies, … cytokine release and cell death pathways; certain cytokines, …

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

I Karwaciak, A Sałkowska, K Karaś, J Dastych… - Vaccines, 2021 - mdpi.com
… for the hyperactivation of monocytes and … monocytes and macrophages, given that a reduced
response from T lymphocytes triggers an uncontrolled cytokine release and cytokine storm

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
… Equally contributed to this work. … high risk of inflammatory cytokine storms caused by
monocytes that may migrate to the lung and further develop into macrophage- or monocyte-derived …

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
… in monocyte abundance … of monocytes to gauge monocyte activation. We noted that
COVID-19 subjects had reduced abundances of HLA-DR on the surface of all classes of monocyte