COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is available
as soon as there are survivors. The COVID-19 pandemic represented the first large-scale …

COVID-19 convalescent plasma and randomized clinical trials: explaining conflicting outcomes and finding signals of efficacy

D Focosi, M Franchini, L Pirofski, T Burnouf, N Paneth… - medRxiv, 2021 - medrxiv.org
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is available
as soon as there are survivors. The COVID-19 pandemic represented the first large-scale …

[HTML][HTML] Factors associated with good patient outcomes following convalescent plasma in COVID-19: a prospective phase II clinical trial

D Ibrahim, L Dulipsingh, L Zapatka, R Eadie… - Infectious diseases and …, 2020 - Springer
… Our results suggest that convalescent plasma with adequate anti-SARS-CoV-2 antibody titer
is safe and has the potential for positive impact on clinical outcomes including recovery and …

[HTML][HTML] COVID-19 convalescent plasma is more than neutralizing antibodies: a narrative review of potential beneficial and detrimental co-factors

D Focosi, M Franchini, L Pirofski, T Burnouf… - Viruses, 2021 - mdpi.com
… experience from China [4], convalescent plasma, old passive immunotherapy used with …
year, overall documenting that COVID-19 convalescent plasma (CCP), if administered at high-…

Outcomes of convalescent plasma with defined high versus lower neutralizing antibody titers against SARS-CoV-2 among hospitalized patients: CoronaVirus …

LA Bartelt, AJ Markmann, B Nelson, J Keys, H Root… - MBio, 2022 - Am Soc Microbiol
… COVID-19 convalescent plasma (CCP) was an early and widely adopted putative therapy
for severe COVID-19. Results from randomized control trials and observational studies have …

[HTML][HTML] Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression

TAC Snow, N Saleem, G Ambler, E Nastouli… - British Journal of …, 2021 - Elsevier
… In patients with COVID-19, there was no clear mortality benefit associated with convalescent
plasma treatment. In patients with mild disease, convalescent plasma did not prevent either …

[HTML][HTML] Convalescent plasma: possible therapy for novel coronavirus disease 2019

H Cao, Y Shi - Transfusion, 2020 - ncbi.nlm.nih.gov
Convalescent plasma might be a potential treatment for COVID‐19.1 Convalescent plasma
refers to a plasma therapy based on plasma or plasma derivatives obtained from donors who …

[HTML][HTML] Convalescent plasma therapy and its effects on COVID-19 patient outcomes: a systematic review of current literature

N Bakhtawar, M Usman, MMU Khan - Cureus, 2020 - ncbi.nlm.nih.gov
plasma therapy improves patient mortality. Until we have concrete evidence to prove otherwise,
convalescent plasma … for any conflicts that were resolved through mutual consultation. …

[HTML][HTML] The emerging role of convalescent plasma in the treatment of COVID-19

T Psaltopoulou, TN Sergentanis, V Pappa… - …, 2020 - journals.lww.com
… Until now the number of COVID-19 patients with known outcomes of convalescent plasma
administration is particularly limited, stemming from 6 case series. The follow-up of cases …

[HTML][HTML] Convalescent plasma therapy for COVID-19: a systematic review and meta-analysis on randomized controlled trials

C Filippatos, I Ntanasis-Stathopoulos, K Sekeri… - Viruses, 2023 - mdpi.com
… Because studies and reviews yielded conflicting results, there has been a persistent lack of
… effect of convalescent plasma treatment on the clinical outcomes of patients with COVID-19. …