Janus kinase inhibitors and coronavirus disease (COVID)-19: rationale, clinical evidence and safety issues

M Gatti, E Turrini, E Raschi, P Sestili, C Fimognari - Pharmaceuticals, 2021 - mdpi.com
… practice to fight the novel coronavirus disease (COVID-19), and … candidate drugs to treat
COVID-19, Janus Kinase (JAK) … remdesivir for the treatment of COVID-19 in hospitalized patients …

Janus kinase (JAK)-inhibitors and coronavirus disease 2019 (Covid-19) outcomes: a systematic review and meta-analysis

RY Limen, R Sedono, A Sugiarto… - Expert Review of Anti …, 2022 - Taylor & Francis
… route of Covid-19 [Citation18]. These properties may offer clinical benefit in preventing the
deterioration of coronavirus disease 2019 (Covid-19) and reducing the death toll from Covid-…

A review of Janus kinase inhibitors for the treatment of Covid-19 pneumonia

Y Tanaka - Inflammation and Regeneration, 2023 - Springer
… factors for disease worsening and death associated with Covid-19 … disease-associated
interstitial lung disease. Anti-MDA5 antibody-positive interstitial lung diseases, which, like Covid-…

The use of Janus kinase inhibitors in the time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

D Peterson, W Damsky, B King - Journal of the American Academy of …, 2020 - jaad.org
… but the risk of Janus kinase inhibitor (JAKi) treatment has not been addressed. In light of
the growing off-label use of JAKis in dermatology in addition to pharmaceutical industry-…

Reply: Calm before the storm: understanding the role of Janus kinase inhibitors in COVID-19

D Peterson, W Damsky, B King - Journal of the American Academy of …, 2020 - jaad.org
… of Janus kinase (JAK) inhibitors in the time of severe acute respiratory syndrome coronavirus
2 (… However, data in the literature regarding the possible use of JAK inhibitors in COVID 19 …

Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection

F Solimani, K Meier, K Ghoreschi - European journal of …, 2021 - Wiley Online Library
… ill COVID-19 patients show genetic polymorphisms in one IFN receptor gene (IFNRA2) and
in a gene locus near the Janus kinase (… understanding on COVID-19 disease and therapeutic …

Use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals

O Melikhov, T Kruglova, K Lytkina… - … Rheumatic Diseases, 2021 - ard.bmj.com
Janus kinase (JAK) inhibitors for the treatment of hospitalised patients with COVID-19 have
been extensively studied. Initially, at the start of the pandemic outside of China, baricitinib …

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19

A Gozzetti, E Capochiani, M Bocchia - Leukemia, 2020 - nature.com
… We would like to report our results in COVID-19 patients with … The median time from the onset
of COVID-19-related … stable disease, and 2/18 patients showed progressive disease. At day …

Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: A systematic review and meta-analysis of randomized controlled trials

CY Chen, WC Chen, CK Hsu, CM Chao… - International …, 2021 - Elsevier
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and has become the biggest threat to global public health since …

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation

F La Rosée, HC Bremer, I Gehrke, A Kehr, A Hochhaus… - Leukemia, 2020 - nature.com
… The disease has been designated COVID-19, an acronym for “coronavirus disease 2019”.
To date, efficacy of antiviral drugs explored in COVID-19 awaits confirmation [2, 3]. …