… of activation of the adaptive immune response. In this study, we directly test the role of
complement in SARS-CoV pathogenesis … of complement even though viral load is unchanged. …

… (aHUS) have implicated the complement pathway in the pathogenesis of COVID‐19, and …
of systemic complement activation that is likely to underpin many of the effects of COVID‐19 …

… The exact pathogenesis of COVID-19 is still poorly understood. SARS-CoV-2 triggers an
excessive and maladaptive systemic inflammatory response, resulting in the sustained release …

… In order to determine whether complement activation is involved in the pathogenic outcomes
observed in patients infected with SARS-CoV, this study used mice genetically null for the …

… coronavirus pathogenesis. … that complement activation is frequent in patients with COVID-19
and probably involved in the pathophysiology of its clinical complications. Complement may …

… role of the different complement activation products in the pathogenesis of COVID-19–…
the hypothesis that blockade of the terminal complement pathway may represent a potential …

… Nevertheless, dysregulated complement activation has been implicated in the development
… by highly pathogenic viruses (12, 13). The complement system can be activated via the …

… As we develop an improved understanding of the pathogenesis of SARS-CoV-2, including …
, dissecting specifically how complement activation contributes to its pathogenesis (as Yu et al …

… Complement associated microvascular injury and thrombosis in the pathogenesis of severe
COVID-19 infection: a report of five cases. Transl Res [online ahead of print] 15 Apr 2020; …

… system, one of the first lines of the host defense and a key player in the innate immune
response, has been implicated in the pathogenesis of severe COVID-19 (14–16). Features of …