… ACE1 and ACE2: ACE1 generates angiotensin II (Ang II) and, in turn, signalling by the
GPCRs AT 1 and AT 2 receptors, while ACE2 … of COVID-19, we emphasize the role of ACE1-…

… In this study, we examined levels of ACE1 and ACE2 in the circulation of two groups of
COVID-19 patients (ICU-admitted and general ward-admitted patients) compared with healthy …

… In a pooled analysis of ACE1 rs4646994, we discovered that COVID-19 positive patients
carrying DD genotype had a 2.06-fold increased risk of developing severe manifestations …

… ACE1 and the rs2285666 SNV of ACE2, we elucidated the prevalence of SNPs in ACE1 and
ACE2 … these SNPs and the global patterns of COVID-19 prevalence. Methods. 66 of the 127 …

… In conclusion, an adverse outcome of COVID-19 was associated with male gender, … and
the ACE1 genotype. Our work suggested that the ACE1-I/D might influence COVID-19 severity, …

… of ACE1 D/D genotype was significantly higher in severe and critical COVID-19 patients (P
= … Although the ACE2 rs2285666 SNP was not related to the severity of disease, this variant …

… The present study is the first to determine the potential role of ACE1/ACE2 gene
polymorphisms in susceptibility to COVID-19 and the disease outcome of COVID-19 with a larger …

… The common polymorphisms of ACE1 and ACE2 genes act to enhance their mutual
expression levels. This might cause fibrosis, hyper coagulation, apoptosis and increased capillary …

… existence of ACE1 and ACE2 in chordates. Multiple events of domain duplication (red spheres)
have happened in the ACE1 subfamily, an important one leading to the vertebrate ACE1, …

… be a possible treatment for COVID-19 patients with a double … ACE2 activity counteracting
unescapably unrestrained ACE1 activity to contrast lung injury. In summary, the ACE1/ACE2 …