CAR T-cell treatment during the COVID-19 pandemic: management strategies and challenges

Y Hu, ETS Yin, Y Yang, H Wu, G Wei, J Su… - Current research in …, 2020 - Elsevier
… However, the risk of conservative suspension of CAR T-cell therapy to avoid the theoretical
CAR T-cell therapy should commence once patients have clinically recovered from COVID-19

[HTML][HTML] Chimeric antigen receptor T cell therapy during the COVID-19 pandemic

…, DL Porter, PA Riedell, CAR T-cell Consortium - Biology of Blood and …, 2020 - Elsevier
… and given the constrained resources and uncertain therapeutic environment during the
COVID-19 pandemic, we suggest deferring these patients from CAR T cell therapy. …

IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19

T Kishimoto, S Kang - Annual review of Immunology, 2022 - annualreviews.org
T cell therapy and coronavirus disease 2019 (COVID-19). Here, we refocus attention on
the biology of IL-6 and summarize the distinct pathological roles of IL-6 signaling in several …

COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

A Busca, J Salmanton-García, P Corradini… - Blood …, 2022 - ashpublications.org
… developing COVID-19 after treatment with CAR T cells. … COVID-19 after the first 6 months
post–CAR T-cell therapy, … a long period of time after cellular therapy. Currently, there are …

Tocilizumab not associated with increased infection risk after CAR T-cell therapy: implications for COVID-19?

MJ Frigault, S Nikiforow, MK Mansour… - Blood, The Journal …, 2020 - ashpublications.org
… shorter course of treatment that is implemented early, as is proposed for therapy of COVID-19–…
Therefore, we investigated infectious complications after tocilizumab use for CAR T-cell–…

Multidisciplinary recommendations for the management of CAR-T recipients in the post-COVID-19 pandemic era

T Zhang, W Tian, S Wei, X Lu, J An, S He… - … Hematology & Oncology, 2023 - Springer
… considering CAR T-cell immunotherapy. Hence, we reviewed the current understanding …
COVID-19 and reported clinical experience in the management of COVID-19 and CAR-T therapy

Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis

C Ge, K Du, M Luo, K Shen, Y Zhou, K Guo… - … hematology & oncology, 2022 - Springer
… response to COVID-19 vaccines in HSCT or CAR T-cell recipients. Our findings may inform
regular COVID-19 vaccination at appropriate intervals after HSCT or CAR T-cell therapy. …

… cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy

P Ljungman, M Mikulska, R de La Camara… - Bone marrow …, 2020 - nature.com
… Since the COVID-19 situation varies substantially between and within countries, we … We
believe that patients having undergone HCT or are receiving CAR T-cell therapy can require …

Brain dysfunction in COVID19 and CART therapy: cytokine storm‐associated encephalopathy

U Pensato, L Muccioli, I Cani, D Janigro… - Annals of Clinical …, 2021 - Wiley Online Library
… with immune effector cell-associated neurotoxicity … T-cell (CAR-T) therapy, a highly effective
treatment for refractory hematological malignancies. We investigated whether COVID-19-…

Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood …

AM Spanjaart, P Ljungman, R de La Camara… - Leukemia, 2021 - nature.com
COVID-19 after B-cell-targeted CAR-T-cell therapy have a very poor outcome. The COVID-19
affected by COVID-19 (Mortality Analyses—Johns Hopkins Coronavirus Resource Center (…