Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
… With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
, a coherent cellular and molecular pathway is proposed for COVID-19. The pathway is …

[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis.
Given the elicited signaling pathways, we introduced possible pathwaysignaling pathways

Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review

L Saba, C Gerosa, D Fanni, F Marongiu… - European Review for …, 2020 - iris.unica.it
… The key clinical features of the patients with SARS-CoV-2, the causative agent of COVID-19, …
multiple molecular pathways through which SARSCoV-2 targets the different cell types in …

Metabolic Perturbations and Severe COVID19 Disease: Implication of Molecular Pathways

E Nigro, F Perrotta, R Polito, V D'Agnano… - International Journal …, 2020 - Wiley Online Library
COVID-19 outcomes. This review investigates the association between metabolic disorders
and COVID-19 severity, exploring the molecular … for more severe COVID-19 outcomes. In …

SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19

DAB Rex, S Dagamajalu, RK Kandasamy… - … and Signaling, 2021 - Springer
… A depiction of host molecular dynamics triggered by SARS-CoV-2 in the form … signaling
molecules will be helpful for COVID-19 research. Therefore, we developed the signaling pathway

PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19

MR Khezri - Human Cell, 2021 - Springer
… that suppression of the PI3K/AKT signaling pathway inhibits NF-κB and AP-… signaling
pathway and ultimately suppress inflammation [10], along with antiviral drugs to combat COVID-19

Inflammatory pathways in COVID19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
signaling pathways. We believe that a comprehensive understanding of the regulatory pathways
of COVID-19 … strategies to effectively control inflammatory diseases, such as COVID-19. …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
… Although we are now starting to understand some of the PRRs and signaling pathways in
COVID-19 pathogenesis, a number of new questions arise. These relate to all aspects of the …

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

DS Battagello, G Dragunas, MO Klein… - Clinical …, 2020 - portlandpress.com
… the potential mechanisms of cellular interaction and signaling pathways, elicited by … of
these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these …

Cellular pathways and molecular events that shape autoantibody production in COVID-19

GJ Tsay, M Zouali - Journal of Autoimmunity, 2024 - Elsevier
… with cell signaling pathways and … In COVID-19, extrafollicular B cell responses were described
in severe cases and their presence correlates with class-switched antibody secreting cell