Trends in COVID-19 therapeutic clinical trials.

K Bugin, J Woodcock - Nature Reviews Drug Discovery, 2021 - go.gale.com
COVID-19 clinical trials landscape. Here, we present our assessment of ongoing COVID-19
therapeutic clinical development efforts worldwide. Surveying the clinical trial landscape …

COVID-19 vaccines: a review of the safety and efficacy of current clinical trials

ZP Yan, M Yang, CL Lai - Pharmaceuticals, 2021 - mdpi.com
… The COVID-19 vaccines in clinical trials have all shown promising immunogenicity with
varying degree of … Grade 3 or above side effects are not common in the clinical trials to date. …

Ongoing and future COVID-19 vaccine clinical trials: challenges and opportunities

R Dal-Ré, LG Bekker, C Gluud, S Holm… - The Lancet Infectious …, 2021 - thelancet.com
… -controlled, randomised clinical trials (RCTs) of COVID-19 vaccine candidates once one or
… and future trials of other COVID-19 vaccine candidates currently in clinical development. …

[HTML][HTML] Clinical trials on drug repositioning for COVID-19 treatment

SGV Rosa, WC Santos - Revista Panamericana de Salud …, 2020 - SciELO Public Health
… In this review, we found 24 clinical trials that have already started with the repositioning of
more than 20 medicines for COVID-19 treatment, such as human immunoglobulin, interferons, …

Ongoing clinical trials for the management of the COVID-19 pandemic

MP Lythgoe, P Middleton - Trends in pharmacological sciences, 2020 - cell.com
… Here, we review currently registered interventional clinical trials for the treatment and
prevention of COVID-19 to provide an overall summary and insight into the global response. …

COVID-19 clinical trials: learning from exceptions in the research chaos

KAO Tikkinen, R Malekzadeh, M Schlegel, J Rutanen… - Nature Medicine, 2020 - nature.com
… of the COVID-19 pandemic. In previous pandemics, large-scale randomized trials were …
of old-fashioned randomization, established clinical-trials networks and imaginative use of …

COVID-19 and readjusting clinical trials

A van Dorn - The Lancet, 2020 - thelancet.com
… Physical distancing to protect patient and researcher safety has been one of the major
disruptions to clinical trial research during COVID-19, but according to Kevin Sheth, chief of …

COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
… controlled trials (RCTs) have reported highly variable efficacy results for COVID-19 CP (CCP),
resulting in uncertainty. We analyzed variables associated with efficacy, such as clinical

The COVID-19 pandemic and new clinical trial activations

JM Unger, H Xiao - Trials, 2021 - Springer
… Our aim was to examine the association of the COVID-19 outbreak with new clinical trial
of the COVID-19 outbreak with new clinical trial activations using data from ClinicalTrials.gov, a …

Clinical trial recovery from COVID-19 disruption.

JZ Xue, K Smietana, P Poda, K Webster… - Nature Reviews Drug …, 2020 - go.gale.com
COVID-19 disruption and the implications for the future conduct of clinical trials, we analysed
data from ClinicalTrials.gov between January and July 2020 and surveyed 245 clinical trial