Endpoints for randomized controlled clinical trials for COVID-19 treatments

LE Dodd, D Follmann, J Wang, F Koenig… - Clinical …, 2020 - journals.sagepub.com
… We evaluate statistical power for possible trial endpoints for COVID-19 treatment trials using
… for COVID-19 treatment trials. We evaluate endpoints according to clinical relevance, ease, …

Nanoparticles in the clinic: An update post COVID19 vaccines

AC Anselmo, S Mitragotri - Bioengineering & translational …, 2021 - Wiley Online Library
… Of particular note, we observe: (i) an increase in the number of clinical trials for 21 of the 29
approved nanoparticles in Table 1 (excluding the newly-added mRNA-1723 and BNT162b2)…

A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19

D Belhadi, N Peiffer-Smadja, FX Lescure… - MedRxiv, 2020 - medrxiv.org
… of therapeutic research for COVID-19, we conducted a review of registered clinical trials. …
novel coronavirus”. We included interventional clinical trials focusing on patients with COVID-19

[HTML][HTML] Systematic review of the registered clinical trials for coronavirus disease 2019 (COVID-19)

R Zhu, Y Gao, SH Robert, J Gao, S Yang… - Journal of translational …, 2020 - Springer
… related clinical research. However, systematic reviews of the registered clinical trials are
still lacking. Therefore, we conducted a systematic review of clinical trials for COVID-19 to …

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

, … Vaccine Prevention Network (CoVPN)/Coronavirus … - Science, 2022 - science.org
… to prevent COVID-19 in phase 3 clinical trials, to date, seven COVID-19 vaccines have been
… safe and effective COVID-19 vaccines (4, 5). The coronavirus efficacy (COVE) phase 3 trial (…

[PDF][PDF] Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need

T Zhang, Y He, W Xu, A Ma, Y Yang… - Science China. Life …, 2020 - med.uminho.pt
… registered clinical trials on COVID-19 in China. A, The curve represents accumulated
numbers of COVID-19 cases since January 12, 2020. Daily registered clinical trials numbers are …

[HTML][HTML] Target product profile analysis of COVID-19 vaccines in phase III clinical trials and beyond: an early 2021 perspective

CD Funk, C Laferrière, A Ardakani - Viruses, 2021 - mdpi.com
clinical trial of 4400 participants, 60% efficacy for the prevention of mild, moderate and severe
COVID-19 … Preliminary indications show that 25 of the 44 COVID-19 cases) were the South …

[HTML][HTML] It is unprecedented: trial management during the COVID-19 pandemic and beyond

EJ Mitchell, K Ahmed, S Breeman, S Cotton… - Trials, 2020 - Springer
… via social media and online networking events and wider experiences of trial managers
amongst some Clinical Trials Units (CTUs), this article presents some of the challenges …

[HTML][HTML] The impact of the COVID-19 pandemic on oncology care and clinical trials

JK Ali, JC Riches - Cancers, 2021 - mdpi.com
… global disruption to clinical practice. This article will review the impact that the pandemic
has had on oncology clinical trials. It will assess the effect of the COVID-19 situation on the …

[HTML][HTML] Obstacles and considerations related to clinical trial research during the COVID-19 pandemic

H Hashem, M Abufaraj, A Tbakhi, I Sultan - Frontiers in medicine, 2020 - frontiersin.org
… Thousands of new patients with COVID-19clinical trials, can be met quickly for COVID-19
clinical trials. However, the sense of urgency to discover efficacious treatments for COVID-19