Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality

N Moradian, M Gouravani, MA Salehi, A Heidari… - European cytokine …, 2020 - Springer
… (ARDS), had higher levels of inflammatory cytokines. The … like COVID-19, is described as
cytokine release syndrome (CRS… an increased level of cytokines that are released from myeloid …

Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex

AC Petrey, F Qeadan, EA Middleton… - Journal of Leucocyte …, 2021 - academic.oup.com
… Because COVID-19 patients are known to have an excessive … examine circulating cytokines
in plasma samples of COVID-19-… cytokines for a more in depth understanding of the cytokine

[HTML][HTML] Cytokine release syndrome (CRS) and nicotine in COVID-19 patients: trying to calm the storm

J Gonzalez-Rubio, C Navarro-Lopez… - Frontiers in …, 2020 - frontiersin.org
syndrome (COVID-19), which is fatal in many cases, and is characterized by a cytokine release
syndrome (CRS… of pro-inflammatory cytokines in order to control this “cytokine storm” and …

[HTML][HTML] Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

J Declercq, KFA Van Damme, E De Leeuw… - The Lancet …, 2021 - thelancet.com
… The current study does not support blocking IL-1 or IL-6 in patients with COVID-19, but
more research is needed to determine whether subgroups of patients might benefit or other …

[HTML][HTML] Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

R Hong, H Zhao, Y Wang, Y Chen, H Cai… - Bone marrow …, 2021 - nature.com
… response during coronavirus disease (COVID-19) can induce cytokine release syndrome
(CRS), which is associated with life-threatening complications and disease progression. This …

Definition and risks of cytokine release syndrome in 11 critically ill COVID-19 patients with pneumonia: analysis of disease characteristics

W Wang, X Liu, S Wu, S Chen, Y Li… - The Journal of …, 2020 - academic.oup.com
COVID-19 infection-related CRS. Our results demonstrate that IL-6 was an early indicator of
CRS in COVID-19… an effective method to treat COVID-19 pneumonia patients with CRS and …

[HTML][HTML] Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy

T Walle, S Bajaj, JA Kraske, T Rösner, CS Cussigh… - Nature Cancer, 2022 - nature.com
… Our results suggest that CRS-related cytokines are commonly induced after COVID-19
vaccination and are not sufficient to establish the diagnosis of CRS. Clinically relevant CRS …

Biomarkers of cytokine release syndrome predict disease severity and mortality from COVID-19 in kidney transplant recipients

I Benotmane, P Perrin, GG Vargas, X Bassand… - …, 2021 - journals.lww.com
… that outcomes were chiefly driven by a cytokine release syndrome (CRS). … with COVID-19
who were recruited in our transplant center between March 4 and April 7, 2020. COVID-19 was …

[HTML][HTML] Amelioration of COVID19‐related cytokine storm syndrome: parallels to chimeric antigen receptor‐T cell cytokine release syndrome

RL Hoiland, S Stukas, J Cooper, S Thiara… - British Journal of …, 2020 - ncbi.nlm.nih.gov
… to have COVID19 CSS had markedly elevated IL6 levels, … serum IL6 values reported in
a patient with COVID19 (Fig 1)… COVID19 with ARDS recorded extreme elevations of IL6 in …

[HTML][HTML] Utilizing tocilizumab for the treatment of cytokine release syndrome in COVID-19

A Hassoun, ED Thottacherry, J Muklewicz… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
… Interleukin 6 (IL-6) is one of the cytokines associated with ARDS related to COVID-19 and
it’… We present 9 patients with confirmed COVID-19 by detection of SARS-CoV 2 via reverse-…