[HTML][HTML] Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
COVID-19 severity, we perform cytokine and multiplex immune profiling in COVID-19 patients.
… Next, we assessed whether this cytokine signature was restricted to critically ill COVID-19

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
… which COVID-19 modulates cytokine profiles, we focused the majority of cytokine analyses
on comparisons between the COVID-19 … The signatures of this common COVID-19 phenotype …

[HTML][HTML] Longitudinal cytokine profile in patients with mild to critical COVID-19

L Ling, Z Chen, G Lui, CK Wong, WT Wong… - Frontiers in …, 2021 - frontiersin.org
cytokine profile varied across different severity of COVID-19 over time. Th1 response and
ARDS-associated cytokines were elevated in patients with increasing severity of COVID-19. IL-…

[HTML][HTML] COVID-19 patients exhibit unique transcriptional signatures indicative of disease severity

AR Daamen, P Bachali, CA Bonham… - Frontiers in …, 2022 - frontiersin.org
… patients also differed in the level of disease severity, we compared clinical feature and
cytokine data of COVID Group 1 and Group 2 patients (Figure 5; Supplementary Table 3). We …

Immune signatures underlying post-acute COVID-19 lung sequelae

IS Cheon, C Li, YM Son, NP Goplen, Y Wu… - Science …, 2021 - science.org
… traits of aged COVID-19 convalescents The levels of most proinflammatory cytokines were
comparable in the blood or respiratory tract of the control and COVID-19 convalescents (fig. S2…

[HTML][HTML] Proinflammatory innate cytokines and distinct metabolomic signatures shape the T cell response in active COVID-19

A Binayke, A Zaheer, J Dandotiya, SK Gupta, S Mani… - Vaccines, 2022 - mdpi.com
… Our results reveal that the TLR-specific proinflammatory cytokine activity by PBMCs and
a plasma metabolic signature correlate with a robust T cell immune response against COVID-19

Differential cytokine signatures of SARS-CoV-2 and influenza infection highlight key differences in pathobiology

AH Karaba, W Zhou, LL Hsieh, A Figueroa… - MedRxiv, 2021 - medrxiv.org
cytokines are upregulated in severe COVID-19. We compared cytokines in COVID-19 versus
… for severe COVID-19, we examined the relationship of BMI to cytokines associated with …

[PDF][PDF] Identification of PBMC-based molecular signature associational with COVID-19 disease severity

H Shaath, NM Alajez - Heliyon, 2021 - cell.com
… in severe and fatal case of COVID-19 [8]. Elevated levels of IL-6 and serum ferritin in non-…
observed inflammatory response in COVID-19, that when over reactive, can lead to cytokine

A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis

AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - MedRxiv, 2020 - medrxiv.org
… Spearman correlations between parameters in the flow cytometry, serology and cytokine
analysis were identified separately in Covid-19 and control cohorts (unless stated otherwise in …

[HTML][HTML] Cytokine signature induced by SARS-CoV-2 spike protein in a mouse model

T Gu, S Zhao, G Jin, M Song, Y Zhi, R Zhao… - Frontiers in …, 2021 - frontiersin.org
IL-6 may contribute to the occurrence of CSS in COVID-19. … phenotype of COVID-19: mAbs
against IL-1α, IL-6, TNF-α, and … JAK partially relieved CSS; mAbs against IL-6, TNF-α, and GM-…