Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
… of COVID-19 in our own centre, when IL-6 was being measured for research purposes rather
than clinical care, we used the following criteria for COVID-CSS: 1) COVID-19 pneumonia …

COVID-19 cytokine storm: the interplay between inflammation and coagulation

RJ Jose, A Manuel - The Lancet Respiratory Medicine, 2020 - thelancet.com
… [TNF], IL-6, and IL-1β) results in what has been described as a cytokine storm, leading to an
… failure, and eventually death when the high cytokine concentrations are unabated over time.…

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
storm and ultimately with their ability to predict the clinical … differences between chemokines
and cytokines, which both … physiopathology of COVID-19-related cytokine storm. This will …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… As seen in the influenza pandemic of 1918, it has been suggested that a cytokine storm of
… which target the COVID-19 induced cytokine storm. As this is not exclusive to COVID-19, we …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
… , this study also supports the possible benefit of anti-TNF agents in the treatment of the
cytokine storm of COVID-19. However, current data is limited, and there are a few small ongoing …

[PDF][PDF] Cytokine storms: understanding COVID-19

N Mangalmurti, CA Hunter - Immunity, 2020 - cell.com
… that a bona fide cytokine storm underlies COVID-19 pathologies, … Perhaps research on
COVID-19 will provide impetus to … of strategies that target cytokines, complement, and coagulation …

[HTML][HTML] The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… Then, a cytokine storm can induce edematous, ARDS, … till now why cytokine storm induces
in only COVID-19 elderly patients… between cytokine storm in elderly patients of COVID-19 and “…

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
… in COVID-19. This review describes critical host and viral factors underpinning the
inflammatory “cytokine storm” induction and IFN antagonism during COVID-19 pathogenesis. …

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
… interference with the cytokine storm as a therapeutic approach to tackle COVID-19. In this …
into the cytokine storm phenomena as one of the key players to COVID-19 aggressiveness and …

COVID-19 cytokine storm syndrome: a threshold concept

LYC Chen, TTT Quach - The Lancet Microbe, 2021 - thelancet.com
… The COVID-19 pandemic has placed the … of COVID-19 cytokine storm syndrome (COVID-19-CSS).
Early in the pandemic, high levels of inflammatory cytokines such as interleukin-6 (IL-6