… dampen the cytokine storm syndrome to save lives. One of the first approaches to treat
COVID-19 cytokine storm syndrome was targeting interleukin-6 (IL-6). Early during the pandemic, …

… global targeting of the inflammation or neutralizing a single key inflammatory mediator,
are being employed to cope with cytokine storm in COVID-19. Among key cytokines, IL-6 has …

… research status of the different cytokines involved. We also … for targeting these cytokines or
related signal pathways. We believe that a comprehensive understanding of CS in COVID-19 …

… The immune dysregulation in severe COVID-19 individuals was driven by IL-6 [12] and the
IL-6 … Therefore, IL-6 may be a potential target cytokine to treat COVID-19 related ARDS. IL-6 …

… are now of interest in order to regulate the cytokine storm, and this review will summarize
and discuss advances in targeted therapies against cytokine storms induced by COVID-19. …

… for ‘COVID-19’ ongoing studies enrolling potential therapeutic drugs related to pathophysiological
mechanisms and cytokine … arthritis treated with immunosuppressive targeted therapies …

… Neutralizing antibodies targeting inflammatory cytokines … COVID-19; however, the complexity
of cytokine interactions and the multiplicity of cytokine targets make attenuating the cytokine …

… and GM-CSF inhibitors in human testing, the need to combine agents targeting different
cytokines is emerging as the likely path forward for supportive care for COVID-19 patients with …

… in the alleviation of COVID‑19 symptoms. In this review, cytokine storms caused by SARS‑…
advances in immunoregulatory therapy strategies for patients with COVID‑19 are reviewed. …

… of COVID-19 disease, suggesting that other off-target effects may be attributed to the drug.
Further studies, particularly amongst patient populations at earlier stages of the disease, are …