COVID-19: drug targets and potential treatments

C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
… To date, no drug or vaccine has been approved to treat the severe disease caused …
coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets

The role of lipid metabolism in COVID-19 virus infection and as a drug target

M Abu-Farha, TA Thanaraj, MG Qaddoumi… - International journal of …, 2020 - mdpi.com
The current Coronavirus disease 2019 or COVID-19 … by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-… cycle, we asked whether drugs targeting lipid metabolism, such as …

A review on novel drug targets and future directions for COVID-19 treatment

YT Wondmkun, OA Mohammed - Biologics: Targets and Therapy, 2020 - Taylor & Francis
… Accordingly, numerous drug targets are identified by … This review summarizes the promising
drug targets for COVID-19… for repurposing the available clinical drugs. In addition, it gives a …

Drug targets for COVID-19 therapeutics: Ongoing global efforts

A Saxena - Journal of biosciences, 2020 - Springer
target the stages in the virus life cycle. In this review, the potential drug targets for drug
and an overview of the current status of drug development against SARS-CoV-2 infection is …

[HTML][HTML] ACE2 as drug target of COVID-19 virus treatment, simplified updated review

G Mostafa-Hedeab - Reports of biochemistry & molecular biology, 2020 - ncbi.nlm.nih.gov
COVID-19 from binding, and consequently cellular entry and injury. Comparatively, soluble
ACE2, which has a higher affinity to COVID-19, can neutralize COVID-19 … of COVID-19 may …

[HTML][HTML] Roles of existing drug and drug targets for COVID-19 management

AG Ayele, EF Enyew, ZD Kifle - Metabolism Open, 2021 - Elsevier
… This review also summarizes plant-based medicines for the treatment of COVID-19 such as
targets being repurposed against COVID-19 and viral elements that are used in COVID-19

A review of COVID-19 biomarkers and drug targets: resources and tools

FP Caruso, G Scala, L Cerulo… - Briefings in …, 2021 - academic.oup.com
… at risk of progression of COVID-19 and their molecular … to identify biomarkers and drug targets
that we review here. … for biomarker identification and drug repurposing. The selected topics …

DeepH-DTA: deep learning for predicting drug-target interactions: a case study of COVID-19 drug repurposing

M Abdel-Basset, H Hawash, M Elhoseny… - Ieee …, 2020 - ieeexplore.ieee.org
… spread of novel coronavirus pneumonia (COVID-19) has led … and relies on the identification
of drug-target (DT) interactions … DT binding affinities for heterogeneous drugs. We propose a …

Artificial intelligence in COVID-19 drug repurposing

Y Zhou, F Wang, J Tang, R Nussinov… - The Lancet Digital …, 2020 - thelancet.com
… -19, including antiviral drugs and host-targeting therapies (figure 1). A detailed discussion
of repurposed drugs for COVID-19 can be found in a review by Sanders and colleagues. …

[HTML][HTML] Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19

A Shah - Frontiers in immunology, 2020 - frontiersin.org
drugs for the treatment of COVID-19. Furthermore, considering the clinical use of several
NLRP3 inhibitor drugs for … potential usefulness of these agents in the treatment of COVID-19. …