Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial

C Salvarani, G Dolci, M Massari, DF Merlo… - JAMA internal …, 2021 - jamanetwork.com
… the assessment of the effect of tocilizumab. To evaluate the efficacy and safety of early
administration of tocilizumab in hospitalized patients with COVID-19 pneumonia, we designed …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
tocilizumab use. This review will continuously evaluate the role of tocilizumab in COVID-19
assess the impact of COVID-19 disease severity on response to tocilizumab therapy. We also …

[HTML][HTML] Effects of Tocilizumab in COVID-19 patients: a cohort study

CA Vu, KJ DeRonde, AD Vega, M Maxam, G Holt… - BMC infectious …, 2020 - Springer
… Due to the lack of proven therapies, we evaluated the effects of early administration of
tocilizumab for COVID-19. By inhibition of the IL-6 receptor, tocilizumab may help to mitigate the …

[HTML][HTML] Effect of tocilizumab in reducing the mortality rate in COVID-19 patients: a systematic review with meta-analysis

V Conti, G Corbi, C Sellitto, F Sabbatino… - Journal of Personalized …, 2021 - mdpi.com
… use of Tocilizumab (TCZ) in COVID-19 are contrasting and inconclusive. This meta-analysis
aimed to assess TCZ effectiveness in reducing the mortality rate in COVID-19 … on COVID-19

The effect of tocilizumab on COVID-19 patient mortality: A systematic review and meta-analysis of randomized controlled trials

WT Lin, SH Hung, CC Lai, CY Wang… - International …, 2021 - Elsevier
… Despite the fact that our findings showed that tocilizumab did not have a positive impact on
COVID-19 patient mortality, we found that tocilizumab was associated with a lower rate of MV …

[HTML][HTML] Effects of tocilizumab on mortality in hospitalized patients with COVID-19: a multicentre cohort study

J Martínez-Sanz, A Muriel, R Ron, S Herrera… - Clinical Microbiology …, 2021 - Elsevier
… In this large observational study, tocilizumab was associated with a lower risk of death or …
While the results of ongoing clinical trials of tocilizumab in patients with COVID-19 will be …

[HTML][HTML] Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
… to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with
… The size of the effects of tocilizumab reported in this paper are therefore an underestimate …

[HTML][HTML] Tocilizumab for treatment of severe COVID-19 patients: preliminary results from SMAtteo COvid19 REgistry (SMACORE)

…, R Bruno, COVID IRCCS San Matteo Pavia Task Force - Microorganisms, 2020 - mdpi.com
… the role of Tocilizumab therapy (TCZ) in terms of ICU admission and mortality rate of critically
ill patients with severe COVID-19 pneumonia. Design: Patients with COVID-19 pneumonia …

[HTML][HTML] Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia: a randomized clinical trial

O Hermine, X Mariette, PL Tharaux… - JAMA internal …, 2021 - jamanetwork.com
effect of IL-6 in COVID-19 pneumonia, 13 -15 we first evaluated the benefit-risk effect of
tocilizumab (TCZ… Tocilizumab is also approved for systemic inflammatory response caused by the …

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

VC Veiga, JAGG Prats, DLC Farias, RG Rosa… - bmj, 2021 - bmj.com
… In patients with severe or critical covid-19, tocilizumab plus standard care was not superior
to standard care alone in improving clinical outcomes at 15 days, and it might increase …