Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences

S Singla, S Goyal - Bulletin of the National Research Centre, 2022 - Springer
… The Clinical Trials.gov databank was searched to find ongoing and completed clinical
trials evaluating the efficacy of molnupiravir against COVID- 19. The screened articles were …

Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a real-world cohort of outpatients with COVID-19 at high risk of progression: the PISA …

G Tiseo, C Barbieri, V Galfo, S Occhineri… - Infectious Diseases and …, 2023 - Springer
… In some reports, molnupiravir has been found to reduce the … the placebo group had a
COVID-19–related hospitalization by … COVID-19 who received nirmatrelvir/ritonavir, molnupiravir, …

Phase 2/3 trial of molnupiravir for treatment of Covid-19 in nonhospitalized adults

Y Caraco, GE Crofoot, PA Moncada… - NEJM …, 2022 - evidence.nejm.org
… In this article, we report safety, efficacy, and virology data from the phase 2, dose-finding
component of a trial evaluating molnupiravir for the treatment of Covid-19 in patients who were …

Safety and efficacy of molnupiravir in SARS‐CoV‐2‐infected patients: A real‐life experience

A De Vito, A Colpani, A Bitti, B Zauli… - Journal of Medical …, 2022 - Wiley Online Library
… Our study shows the efficacy and safety of molnupiravir in a real-life cohort that included a
high … to evaluate the impact of molnupiravir in the progression of COVID-19, identify the best …

Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised …

WHK Schilling, P Jittamala, JA Watson… - The Lancet Infectious …, 2024 - thelancet.com
… antiviral activity in patients with early COVID-19 compared with molnupiravir. Candidate
antivirals and antiviral combinations for COVID-19 should be assessed and compared using this …

Molnupiravir for treatment of adults with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials

Y Gao, M Liu, Z Li, J Xu, J Zhang, J Tian - Clinical Microbiology and …, 2023 - Elsevier
… assess the efficacy and safety of molnupiravir in patients with mild or moderate COVID-19. …
thus far of the efficacy and safety of molnupiravir in treating patients with mild-to-moderate …

Effect of molnupiravir on biomarkers, respiratory interventions, and medical services in COVID-19: a randomized, placebo-controlled trial

MG Johnson, A Puenpatom, PA Moncada… - Annals of internal …, 2022 - acpjournals.org
… trial established the efficacy and safety of molnupiravir in nonhospitalized adults with
mild to moderate COVID-19 and risk factors for progression to severe disease. Molnupiravir (800 …

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

WA Fischer, JJ Eron Jr, W Holman, MS Cohen… - Science translational …, 2021 - science.org
… These sensitivity analyses indicated that the antiviral efficacy of molnupiravir demonstrated
in this study was not due to imbalances in seropositivity, trends in viral RNA at baseline, or …

Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

GR Painter, MG Natchus, O Cohen, W Holman… - Current opinion in …, 2021 - Elsevier
… Here, we describe the evolution of molnupiravir (EIDD-2801, MK-4482), a broad-spectrum …
prevention and treatment of COVID-19. When the pandemic began, molnupiravir was in pre-…

Antiviral efficacy and safety of molnupiravir against omicron variant infection: a randomized controlled clinical trial

R Zou, L Peng, D Shu, L Zhao, J Lan, G Tan… - Frontiers in …, 2022 - frontiersin.org
… to evaluate the clinical efficacy of molnupiravir for COVID-19 patients infected with Omicron
… the antiviral efficacy between patients who were treated with molnupiravir plus basic …