Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs

LD Saravolatz, S Depcinski… - Clinical Infectious …, 2023 - academic.oup.com
efficacy of molnupiravir in the treatment of COVID-19. Among 202 treated participants, virus
isolation was significantly lower in participants receiving 800 mg molnupiravir (… molnupiravir

Safety and efficacy of antivirals against SARS-CoV-2

DB Sidebottom, DD Smith, D Gill - bmj, 2021 - bmj.com
… the efficacy of 800 mg molnupiravir twice daily for five days given within five days of the onset
of mild or moderate covid-19 … An earlier trial (Move-In) of molnupiravir in hospital inpatients …

An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19

AK Singh, A Singh, R Singh, A Misra - Diabetes & Metabolic Syndrome …, 2022 - Elsevier
… We found full published results of phase 3, double-blind, randomized study (MOVe-OUT)
that was planned to assess efficacy and safety of molnupiravir in 1433 non-hospitalized adult (…

[HTML][HTML] Cost-effectiveness analysis of molnupiravir versus best supportive care for the treatment of outpatient COVID-19 in adults in the US

H Goswami, A Alsumali, Y Jiang, M Schindler… - …, 2022 - Springer
… with COVID-19, through … molnupiravir demonstrated significant efficacy versus placebo in
reducing hospitalization or death among unvaccinated adults with mild-to-moderate COVID-19

Why molnupiravir fails in hospitalized patients

AN Brown, Y Lang, J Zhou, EJ Franco, KC Hanrahan… - Mbio, 2022 - Am Soc Microbiol
Molnupiravir is an antiviral that has shown clinical efficacy against mild-to-moderate COVID-19
but … Our findings illustrated that molnupiravir was most effective at combatting COVID-19

Is molnupiravir a wise investment? Reassessing COVID-19 treatment strategies

CS Kow, DS Ramachandram… - Journal of Antimicrobial …, 2023 - academic.oup.com
… drugs indicated for COVID-19 such as molnupiravir, we must … the potential to reduce mortality
associated with COVID-19. … provided compelling evidence of the efficacy of molnupiravir

[HTML][HTML] Real-world clinical outcomes of treatment with molnupiravir for patients with mild-to-moderate coronavirus disease 2019 during the Omicron variant pandemic

Y Suzuki, Y Shibata, H Minemura, T Nikaido… - Clinical and …, 2023 - Springer
… We here evaluated the efficacy of molnupiravir in patients with mild-to-moderate coronavirus
disease 2019 (COVID-19) during the Omicron variant surge in Fukushima Prefecture, Japan…

Real-world Effectiveness of Molnupiravir and Nirmatrelvir/Ritonavir as Treatments for COVID-19 in Patients at High Risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
… , we aimed to evaluate the effectiveness of molnupiravir and nirmatrelvir/ritonavir in patients
… Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against …

[HTML][HTML] Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2

W Holman, W Holman, S McIntosh, W Painter… - Trials, 2021 - Springer
… On day 50 of the project, the sponsor submitted a phase 2/3 protocol to FDA for a study of
molnupiravir in patients with symptomatic COVID-19 not requiring hospitalization. FDA …

Safety Profile of Molnupiravir with Significant Effect on COVID-19: A Review

T Mukherjee, P Mal, AK Upadhyay… - Current Drug …, 2023 - ingentaconnect.com
COVID-19 [11, 12]. This review aimed to give an overview of recently discovered Merck’s
molnupiravir, demonstrating its safety and efficacy … new COVID protocol in a sequential manner. …