Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

JS Tregoning, KE Flight, SL Higham, Z Wang… - Nature reviews …, 2021 - nature.com
escape variants evolving. In this Progress article, we cover recent developments in COVID-19
… 2021, including real-world data on vaccine effectiveness and the impact of viral variants. …

Analysis of immune escape variants from antibody-based therapeutics against COVID-19: a systematic review

D Focosi, F Maggi, M Franchini, S McConnell… - International journal of …, 2021 - mdpi.com
… reports of documented immune escape after treatment with monoclonal antibodies and
COVID-19-… to better understand immune escape frequencies and the fitness of emerging variants. …

Present variants of concern and variants of interest of severe acute respiratory syndrome coronavirus 2: their significant mutations in S‐glycoprotein, infectivity, re …

C Chakraborty, M Bhattacharya… - Reviews in Medical …, 2022 - Wiley Online Library
… contain the spread of variants. Similarly, due … variant, a steady rise of COVID-19 cases was
noted in India. The spread of the variant has created a second wave of infection of COVID-19

[HTML][HTML] Review of COVID-19 variants and COVID-19 vaccine efficacy: what the clinician should know?

D Vasireddy, R Vanaparthy, G Mohan… - Journal of clinical …, 2021 - ncbi.nlm.nih.gov
… Data show that two of the three mutations in this variant are resistant to antibodies and also
possess the ability to escape the body’s natural acquired immunity to COVID-19, and as such…

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

E Andreano, G Piccini, D Licastro… - Proceedings of the …, 2021 - National Acad Sciences
… and the receptor-binding domain to escape potent polyclonal neutralizing responses. …
COVID-19 convalescent donor. Only three mutations were sufficient to generate this escape variant

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

D Geers, MC Shamier, S Bogers, G den Hartog… - Science …, 2021 - science.org
… to variant antigens, indicating that the B.1.1.7 and B.1.351 S proteins do not escape T cell–…
In conclusion, this study shows that some variants can partially escape humoral immunity …

[HTML][HTML] SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

E Andreano, G Piccini, D Licastro, L Casalino… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… to escape even a potent polyclonal serum targeting multiple neutralizing epitopes. These
results are remarkable because while escape … the evolution of escape variants and because …

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries

R Wang, J Chen, K Gao, GW Wei - Genomics, 2021 - Elsevier
… more infectious SARS-CoV-2 variants. Considering mutation occurrence probability and
ability to disrupt antibodies, we identify vaccine-escape and vaccine-weakening RBD mutations. …

COVID-19 vaccines vs variants—determining how much immunity is enough

R Rubin - Jama, 2021 - jamanetwork.com
… One reason SARS-CoV-2 is throwing out variants and will continue … reduced efficacy of
COVID-19 vaccines against some variants. But … Is it likely that 'escape' of variants from binding by …

Emergence of drift variants that may affect COVID-19 vaccine development and antibody treatment

T Koyama, D Weeraratne, JL Snowdon, L Parida - Pathogens, 2020 - mdpi.com
… plasma from patients who have recovered from COVID-19. The coronavirus genome is highly
prone to mutations that lead to genetic drift and escape from immune recognition; thus, it is …