Functional exhaustion of type I and II interferons production in severe COVID-19 patients

C Ruetsch, V Brglez, M Cremoni, K Zorzi… - Frontiers in …, 2021 - frontiersin.org
… Our results confirmed a functional exhaustion of type I (NK cells and DCs) and type II IFN (T
cells) production in moderate and severe patients traducing an evasion of both innate and …

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

M Zheng, Y Gao, G Wang, G Song, S Liu… - Cellular & molecular …, 2020 - nature.com
… in COVID-19 patients than those in HCs. Consistent with these findings, COVID-19 patients
also … results suggest the functional exhaustion of cytotoxic lymphocytes in COVID-19 patients. …

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

HY Zheng, M Zhang, CX Yang, N Zhang… - Cellular & molecular …, 2020 - nature.com
… in the level of exhaustion modules, including PD-1, CTLA-4, and TIGIT, and functional
modules, … In conclusion, our study identified potential immunological risk factors for COVID-19

Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)

B Diao, C Wang, Y Tan, X Chen, Y Liu, L Ning… - Frontiers in …, 2020 - frontiersin.org
… Taken together, we conclude that T cells are decreased and exhausted in patients with
COVID-19. Cytokines such as IL-10, IL-6, and TNF-α might be involved in T cell reduction. Thus, …

A comprehensive review about immune responses and exhaustion during coronavirus disease (COVID-19)

RN Mohammed, R Tamjidifar, HS Rahman… - Cell Communication and …, 2022 - Springer
… The cytotoxic CD8 + T cells in adaptive immune responses demonstrated functional exhaustion
through upregulation of exhaustion markers. In this regard, humoral immune responses …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
… CD8 + T cells in the respiratory tract are exhausted or functional in patients with COVID-19. …
T cells and clarify whether CD8 + T cells are truly exhausted during the course of COVID-19. …

Immunologic features in coronavirus disease 2019: functional exhaustion of T cells and cytokine storm

S Mahmoudi, M Rezaei, N Mansouri, M Marjani… - Journal of clinical …, 2020 - Springer
COVID-19. However, little is known about lymphocyte subsets and the immune response of
patients with COVID-19 … , and lymphocyte subsets in the cases with severe form of COVID-19. …

[HTML][HTML] Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities

M Alahdal, E Elkord - Clinical Immunology, 2022 - Elsevier
… -activation and exhaustion of innate and adaptive immune cells in COVID-19, which …
exhausted T cells isolated from COVID-19 patients restored T cell functional response to COVID-19 […

Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

M Li, W Guo, Y Dong, X Wang, D Dai, X Liu… - Frontiers in …, 2020 - frontiersin.org
… Conclusions: The functional exhaustion and other subset alteration of NK and T cells
may contribute to the progression and improve the prognosis of COVID-19. Surveillance of …

Dysfunctional state of T cells or exhaustion during chronic viral infections and COVID-19: a review

KP Mishra, M Singh, D Saraswat, L Ganju… - Viral …, 2022 - liebertpub.com
… Still, recent pieces of evidence indicated that the level of circulating T cells is reduced, and
their function is impaired in patients suffering from COVID-19 and especially in those admitted …