Targeting GM-CSF in COVID-19 pneumonia: rationale and strategies

A Bonaventura, A Vecchié, TS Wang, E Lee… - Frontiers in …, 2020 - frontiersin.org
GM-CSF axis in COVID-19COVID-19 lung injury, the marked elevation in GM-CSF levels
as part of the cytokine storm during the onset of COVID-19 pneumonia suggests that GM-CSF

GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

FM Lang, KMC Lee, JR Teijaro, B Becher… - Nature Reviews …, 2020 - nature.com
… increased production of GM-CSF in patients with COVID-19 represents a physiological …
We, along with others 1,72 , suggest that in patients with COVID-19, dysregulated GM-CSF

G-CSF and GM-CSF are different. Which one is better for COVID-19?

HM Lazarus, RP Gale - Acta haematologica, 2021 - karger.com
… more likely to use G-CSF than GM-CSF in persons with COVID-19-related ARDS. This may
… G-CSF-induced influx of granulocytes in the lung, an effect not seen with GM-CSF. However, …

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study

G De Luca, G Cavalli, C Campochiaro… - The Lancet …, 2020 - thelancet.com
… effect of GM-CSF inhibition in COVID-19 and support further … Granulocyte–macrophage
colony-stimulating factor (GM-CSFCOVID-19 pneumonia by inhibition of the GM-CSF pathway. …

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

RS Thwaites, A Sanchez Sevilla Uruchurtu… - Science …, 2021 - science.org
GM-CSF levels in both ICU and non-ICU treated COVID-19 … of GM-CSF + Th1 cells in patients
with COVID-19 requiring ICU … Additionally, a population of IL-17A and GM-CSF expressing …

GM-CSF neutralization with lenzilumab in severe COVID-19 pneumonia: a case-cohort study

Z Temesgen, M Assi, FNU Shweta, P Vergidis… - Mayo Clinic …, 2020 - Elsevier
… -stimulation in COVID-19 and … GM-CSF in the treatment of COVID-19. Lenzilumab was
offered through a compassionate single-use IND to patients with severe and critical COVID-19

GM-CSF in the treatment of COVID-19: a new conductor in the pathogenesis of cytokine storm?

EG Favalli, R Caporali - The Lancet Rheumatology, 2020 - thelancet.com
… strategy to prevent mortality due to COVID-19. In this respect, … in the treatment of severe
COVID-19 and is still being tested in … being tested as potential treatment targets in COVID-19. 6 …

First clinical use of lenzilumab to neutralize GM-CSF in patients with severe and critical COVID-19 pneumonia

Z Temesgen, M Assi, P Vergidis, SA Rizza, PR Bauer… - Medrxiv, 2020 - medrxiv.org
… to neutralize GM-CSF in the treatment of COVID-19. … patients with severe and critical
COVID-19 pneumonia. Based on … -induced GM-CSF depletion prevents CRS in COVID-19 and …

A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR)

J Patel, D Bass, A Beishuizen, XB Ruiz… - European …, 2023 - Eur Respiratory Soc
… of GM-CSF and myeloid cells in COVID-19 pathogenesis [10… Anti-GM-CSF namilumab
demonstrated a reduction in CRP in … of anti-GM-CSF monotherapy in COVID-19 may be linked to …

[HTML][HTML] Granulocyte-macrophage colony stimulating factor in COVID-19: friend or foe?

P Mehta, RC Chambers, L Dagna - The Lancet. Rheumatology, 2021 - ncbi.nlm.nih.gov
GM-CSF,4, 5 and there is accumulating evidence for targeting GM-CSF in patients with severe
COVID-19… Bronchoalveolar lavage fluid analysis from patients with severe COVID-19 has …