[HTML][HTML] Diagnostics for COVID-19: moving from pandemic response to control

RW Peeling, DL Heymann, YY Teo, PJ Garcia - The Lancet, 2022 - thelancet.com
… to be crucial to the COVID-19 pandemic response. There are … tests (which detect the host's
response to infection or vaccination… All three types of COVID-19 test continue to have a crucial …

[HTML][HTML] The immune response to SARS-CoV-2 and COVID-19 immunopathology–Current perspectives

JL Boechat, I Chora, A Morais, L Delgado - Pulmonology, 2021 - Elsevier
… Disease severity in COVID-19 appears to be modulated not just by viral infection but also
by aberrant immune and inflammatory responses in the host. Recent data suggest that this …

COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
… and showed reduced viral replication and aberrant host inflammatory response. In addition,
dihydroorotate dehydrogenase (DHODH) inhibitors were shown to be effective in infected …

[HTML][HTML] Imbalanced host response to SARS-CoV-2 drives development of COVID-19

D Blanco-Melo, BE Nilsson-Payant, WC Liu, S Uhl… - Cell, 2020 - cell.com
response of SARS-CoV-2 with other respiratory viruses to identify transcriptional signatures
that may underlie COVID-19 … Despite virus replication, the host response to SARS-CoV-2 …

Biomaterials-based opportunities to engineer the pulmonary host immune response in COVID-19

BM Jarai, Z Stillman, K Bomb, AM Kloxin… - ACS biomaterials …, 2020 - ACS Publications
host’s pulmonary immune response and its contributions to disease severity and systemic
inflammation. Comparing to frontline COVID-19 … of the host response using biomaterials and …

[HTML][HTML] Host directed therapies: COVID-19 and beyond

D Tripathi, M Sodani, PK Gupta, S Kulkarni - Current research in …, 2021 - Elsevier
… Dexamethasone: Enhanced proinflammatory response is associated with the severity of
COVID-19 disease; therefore, use of anti-inflammatory drugs at the right time might be helpful in …

Heightened innate immune responses in the respiratory tract of COVID-19 patients

Z Zhou, L Ren, L Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - Cell host & …, 2020 - cell.com
… To understand the cytokine profile in BALF from the COVID-19 patients, we assigned DEGs
into … These observations suggested that the exuberant inflammation in COVID-19 could be …

COVID-19, immune system response, hyperinflammation and repurposingantirheumatic drugs

A Tufan, AA Güler… - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
… be considered as treatment choices for COVID-19, particularly in severe … COVID-19, we
have focused the attention on the structural features of SARS-CoV-2, the host immune response

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
… in COVID-19 by targeting the host response to the virus has been made. However, their use
needs to be deepened, since ACE inhibitors and angiotensin II-receptor blockers have been …

COVID-19 pathophysiology: A review

K Yuki, M Fujiogi, S Koutsogiannaki - Clinical immunology, 2020 - Elsevier
… immune response to COVID-19host receptors (attachment), they enter host cells through
endocytosis or membrane fusion (penetration). Once viral contents are released inside the host