TLRs in COVID-19: How they drive immunopathology and the rationale for modulation

FL Mabrey, ED Morrell, MM Wurfel - Innate immunity, 2021 - journals.sagepub.com
… In this review, we detail the mechanism for this imbalance in COVID-19 based on available
evidence, and we discuss how modulation of critical elements may be important in reducing …

[HTML][HTML] Immunopathology of SARS-CoV-2 infection: immune cells and mediators, prognostic factors, and immune-therapeutic implications

A Allegra, M Di Gioacchino, A Tonacci… - International journal of …, 2020 - mdpi.com
… The present is a comprehensive review of the immunopathology of Covid-19. The immune
… , and activation of other pathogen resistance mechanisms. We fully address the humoral and …

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
… widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). Indeed, in
mechanism on why certain sub-populations are more likely to die of COVID-19 than others. …

Immunopathology in COVID-19

AMSR Bagorro - 2021 - repositorio.ul.pt
… The new Coronavirus – SARS-CoV-2 – gave rise to COVID-19, an infection that … the
mechanisms by which the infection proceeds, as well as its main elements. The immunopathology

A scoping review of the pathophysiology of COVID-19

PE Marik, J Iglesias, J Varon… - … of immunopathology and …, 2021 - journals.sagepub.com
… overview of the major pathogenetic mechanism leading to severe COVID-19 disease. …
phase of COVID-19, we believe that two major pathogenetic processes cause severe COVID-19, …

[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
… The precise mechanisms of immunopathology in COVID-19 remain elusive. Sustained IL-6
and TNF production in patients infected with SARS-CoV-2 correlates with reduced monocyte …

COVID-19 hyperinflammation: what about neutrophils?

A Didangelos - MSphere, 2020 - Am Soc Microbiol
COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The
immunopathological mechanisms … to identify possible COVID-19 inflammatory mechanisms and …

Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19

R Kumar, H Rathi, A Haq, SJ Wimalawansa, A Sharma - Virus research, 2021 - Elsevier
COVID-19 patients. Thus, this review addresses pathogenesis of SARS-CoV-2 and mechanisms
… immune evasion mechanisms for the successful eradication of pathogen from the host. …

[HTML][HTML] COVID-19 immunobiology: lessons learned, new questions arise

A Kaklamanos, K Belogiannis, P Skendros… - Frontiers in …, 2021 - frontiersin.org
… for COVID-19 and … immunopathological mechanisms that drive COVID-19 pathogenesis,
could help identify the right timing for specific therapies (like interferons). Moreover, if COVID-19

Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies

T Zhou, TT Su, T Mudianto, J Wang - Journal of Experimental Medicine, 2020 - rupress.org
… The outbreak of coronavirus disease 2019 (COVID-19) is an … lymphopenia, with unknown
immunopathological mechanisms. … lens, discussing possible mechanisms of the asynchronized …