Elevated interleukin-10 levels in COVID-19: potentiation of pro-inflammatory responses or impaired anti-inflammatory action?

H Islam, TC Chamberlain, AL Mui, JP Little - Frontiers in Immunology, 2021 - frontiersin.org
… of IL-10 as a driver of cytokine storms during COVID-19 and consider resistance to IL-10’s …
underlying elevated IL-10 levels in patients with severe COVID-19 (summarized in Figure 1)…

[PDF][PDF] Use interleukin-10 as the therapeutic agent for COVID-19

WC Hu - OSF Preprint at https://doi. org/10.31219/osf. io/arfhb, 2020 - scholar.archive.org
… the cytokine-interleukin 10 is key for host 182 immunological pathway against viruses. IL-10
is also … Since COVID-19 is a 184 coronavirus disease and is usually complicated with acute …

A potential role of interleukin 10 in COVID-19 pathogenesis

L Lu, H Zhang, DJ Dauphars, YW He - Trends in Immunology, 2021 - cell.com
… storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10
(IL-10)… early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity. …

Elevated levels of pleiotropic interleukin-6 (IL-6) and interleukin-10 (IL-10) are critically involved with the severity and mortality of COVID-19: An updated longitudinal …

S Jafrin, MA Aziz, MS Islam - Biomarker Insights, 2022 - journals.sagepub.com
… The specific search terms used for this study were: “COVID-19” OR “SARS-Cov-2”; “interleukin-6
“ OR “IL-6”; and “interleukin-10” OR “IL-10.” The search strategy for each database is …

Circulating levels of interleukin-6 and interleukin-10, but not tumor necrosis factor-alpha, as potential biomarkers of severity and mortality for COVID-19: systematic …

W Udomsinprasert, J Jittikoon… - Journal of clinical …, 2021 - Springer
… including IL-6, IL-10, and TNF-α in the severity and mortality of COVID-19. Overall, our results
… of IL-6 and IL-10 in both patients with severe COVID-19 and non-survivors, which confirm …

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19

OJ McElvaney, BD Hobbs, D Qiao, OF McElvaney… - …, 2020 - thelancet.com
… We studied the relationship between the ratio of interleukin (IL)-6 to IL-10 and clinical
outcome in 80 patients hospitalized for COVID-19, and created a simple 5-point linear score …

[HTML][HTML] Interleukin-1β and interleukin-10 profiles and ratio in serum of COVID-19 patients and correlation with COVID-19 severity: a time series study

R Yudhawati, S Sakina, M Fitriah - International Journal of General …, 2022 - ncbi.nlm.nih.gov
… This study aimed to determine whether serum levels of IL-1β and IL-10 and the ratio of the
two over time in patients with COVID-19 could facilitate early identification of disease severity. …

Lung protection vs. infection resolution: interleukin 10 suspected of double-dealing in COVID-19

HA Lindner, SY Velasquez, M Thiel… - Frontiers in …, 2021 - frontiersin.org
… over 2.3 million deaths globally attributed to COVID-19 at the time of writing (… COVID-19
that identified increased blood levels of the major anti-inflammatory cytokine interleukin 10 (IL-10

T-Cell subsets and interleukin-10 levels are predictors of severity and mortality in COVID-19: A systematic review and meta-analysis

AF Alshammary, JM Alsughayyir, KK Alharbi… - Frontiers in …, 2022 - frontiersin.org
… and higher levels of IL-10. Conclusion: Our findings reveal that the level of CD4/CD8 T-cells
and IL-10 are reliable predictors of severity and mortality in COVID-19 patients. The study …

… interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19)

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
… Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune …
cytokine response to COVID-19, by assessing interleukin-10 (IL-10) and IL-10/lymphocyte …