Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies

G Ragia, VG Manolopoulos - European journal of clinical pharmacology, 2020 - Springer
… tract disease which has been named coronavirus disease 19 (COVID-19). The two
previously … were SARS-CoV and the Middle East respiratory syndrome coronavirus (MERS-CoV). …

Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19

KK Oh, M Adnan, DH Cho - Scientific reports, 2021 - nature.com
molecular docking test (MDT). Geneset enrichment analysis exhibited 26 signaling pathways
against COVID-19. … signaling pathway was identified as the key anti-COVID-19 mechanism …

SARS-CoV-2 envelope (E) protein binds and activates TLR2 pathway: a novel molecular target for COVID-19 interventions

R Planès, JB Bert, S Tairi, L BenMohamed, E Bahraoui - Viruses, 2022 - mdpi.com
COVID-19, the present study analyzed the interaction between the SARS-CoV-2 envelope
(E) protein and human TLR2 at the molecular … the TLR2 signaling pathway which culminates …

Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets

MC Proto, D Fiore, C Piscopo, C Pagano… - Progress in lipid …, 2021 - Elsevier
… could be used in Coronavirus Disease 2019 (COVID-19) as … the cell membrane, could be
useful in COVID-19 patients [42]. … to abrogate cardiovascular risk in COVID-19/FH subjects [43]. …

[HTML][HTML] Molecular immune pathogenesis and diagnosis of COVID-19

X Li, M Geng, Y Peng, L Meng, S Lu - Journal of pharmaceutical analysis, 2020 - Elsevier
… Patients with COVID-19 show clinical manifestations including … Hence, although the
pathogenesis of COVID-19 is poorly … -CoV-2 infection to facilitate our recognition of COVID-19. …

Deciphering the molecular pathways underlying dopaminergic neuronal damage in Parkinson's disease associated with SARS-CoV-2 infection

Q Xu, S Jiang, R Kang, Y Wang, B Zhang… - Computers in Biology and …, 2024 - Elsevier
… To elucidate the functional characteristics of common DEGs in PD and COVID-19 DA neurons,
we conducted a series of enrichment analyses using the Enrichr gene set enrichment tool …

Tissue-specific pathway activities: a retrospective analysis in COVID-19 patients

N Pham, F Hu, CT Evelo, M Kutmon - Frontiers in immunology, 2022 - frontiersin.org
molecular mechanisms of COVID-19 in different tissues using proteomics data and pathway
… multi-organ proteomics data to study the molecular pathway activity in COVID-19 patients. …

Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy

T Shibabaw - Journal of inflammation research, 2020 - Taylor & Francis
Coronavirus disease 2019 (COVID-19) is a globally communicable public health disease …
acute respiratory syndrome coronavirus 2 (SARS‐CoV-2). Eradication of COVID-19 appears …

Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking

Z Tianyu, G Liying - Bioengineered, 2021 - Taylor & Francis
… the possible molecular mechanisms of XBJ injection when treating COVID-19 via computer
… signaling pathways, provide a molecular basis to investigate the mechanisms by which the …

Molecular and clinical prognostic biomarkers of COVID-19 severity and persistence

G Papadopoulou, E Manoloudi, N Repousi, L Skoura… - Pathogens, 2022 - mdpi.com
… and KEGG pathway analysis of PBMCs of COVID-19 patients revealed that the main causes
of lymphopenia might be the activation of apoptotic and P53 signaling pathways. Specifically…