The Antiviral Mechanism of Action of Molnupiravir in Humans with COVID-19

TP Sheahan, LJ Stevens, TM Narowski, TJ Krajewski… - medRxiv, 2023 - medrxiv.org
… Thus, potent, broadly-acting oral antivirals targeting the CoV family are needed to treat those
at high risk for severe COVID-19 as well as future emerging CoV infections. For an antiviral …

Molnupiravir—a novel oral anti-SARS-CoV-2 agent

CC Lee, CC Hsieh, WC Ko - Antibiotics, 2021 - mdpi.com
COVID-19. To benefit individual and public health, clinical applications of molnupiravir to
promptly treat COVID-19 … We believe that early molnupiravir treatment in asymptomatic or mildly …

A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval

NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
… avenue for COVID-19 treatment. Recently, molnupiravir is a prodrug antiviral medication
that was approved in the United Kingdom in November 2021 for the treatment of COVID-19. On …

Preliminary clinical experience of molnupiravir to prevent progression of COVID-19 in kidney transplant recipients

M Villamarín, E Márquez-Algaba, J Esperalba… - …, 2022 - journals.lww.com
… The present study describes the favorable evolution of a series of KTRs with COVID-19
treated with molnupiravir compared with a cohort of patients receiving remdesivir. …

Molnupiravir when used alone seems to be safe and effective as outpatient COVID-19 therapy for hemodialyzed patients and kidney transplant recipients

P Poznański, H Augustyniak-Bartosik, A Magiera-Żak… - Viruses, 2022 - mdpi.com
… The most severe symptoms of COVID-19 (fever, muscle and joint … treatment with molnupiravir
in all the patients from the group not requiring admission to the hospital due to COVID-19 (ie…

Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised …

WHK Schilling, P Jittamala, JA Watson… - The Lancet Infectious …, 2024 - thelancet.com
Molnupiravir and ritonavir-boosted nirmatrelvir are the two leading oral COVID-19 antiviral
treatments, … The aim of this ongoing platform trial is to compare different antiviral treatments

Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports

E Mahase - 2021 - bmj.com
molnupiravir reduced the risk of admission to hospital or death by around 50% in non-hospitalised
adults who had mild to moderate covid-19molnupiravir group discontinued treatment

Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission …

CKH Wong, ICH Au, KTK Lau, EHY Lau… - The Lancet Infectious …, 2022 - thelancet.com
… period were defined as having treatment exposure. Because all public … COVID-19 as clinically
appropriate on the basis of the same set of standard treatment protocols, and molnupiravir

Effectiveness of molnupiravir and nirmatrelvir–ritonavir in hospitalized patients with COVID-19: a target trial emulation study

EYF Wan, VKC Yan, AHY Mok, B Wang… - Annals of internal …, 2023 - acpjournals.org
… Our results also showed a larger magnitude of risk reduction with molnupiravir treatment
in older people than in younger people. Our findings provide evidence for the use of …

Molnupiravir for the treatment of non-severe COVID-19: a systematic review and meta-analysis of 14 randomized trials with 34 570 patients–authors' response

M Sun, H Lai, Z Zhang, L Ge - Journal of Antimicrobial …, 2023 - academic.oup.com
… Indeed, for vulnerable groups and patients with severe or critical severe COVID-19, we …
mortality with molnupiravir treatment.We share your concerns about the efficacy of molnupiravir, …