Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

SH Khoo, R Fitzgerald, T Fletcher… - Journal of …, 2021 - academic.oup.com
… Whether or not molnupiravir will prove effective in treating COVID-19 will be determined
in … of potent antiviral agents in the COVID-19 pipeline strongly argues for such accelerated …

Molnupiravir Outpatient Treatment for Adults with COVID-19 in a Real-World Setting—A Single Center Experience

K Czarnecka, P Czarnecka, O Tronina… - Journal of Clinical …, 2022 - mdpi.com
… high risk of severe COVID-19 treated with molnupiravir. Methods: … , COVID-19 symptoms
with the onset of up to 5 days, and at high risk of severe COVID-19 illness received molnupiravir

SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

P Li, Y Wang, M Lavrijsen, MM Lamers, AC de Vries… - Cell research, 2022 - nature.com
… Nevertheless, our findings support the use of molnupiravir and nirmatrelvir for treating
studies to evaluate the combination of molnupiravir and nirmatrelvir for treating COVID-19. …

Why molnupiravir fails in hospitalized patients

AN Brown, Y Lang, J Zhou, EJ Franco, KC Hanrahan… - Mbio, 2022 - Am Soc Microbiol
… explained why molnupiravir failed for the treatment of COVID-19 in … that molnupiravir was
most effective at combatting COVID-19 … Currently available COVID-19 vaccines are unable to …

Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
molnupiravir), (iii) summarizes the clinical progress of other oral antivirals for use in COVID-19
Oral COVID-19 antivirals represent a part of the strategy to adapt to long-term co-existence …

Will Molnupiravir be the First Oral Treatment for High-Risk Non-Hospitalized Patients with Mild-Moderate COVID-19?

S Rao, M Singh - DHR Proceedings, 2021 - dhrproceedings.org
… any treatment that has received full FDA approval for COVID-19. Numerous agents have
been approved under EUA for the treatment … use under EUA for the treatment of mild-moderate …

A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy

N Sakander, A Ahmed, M Bhardwaj, D Kumari… - Bioorganic …, 2024 - Elsevier
… is found to be the first orally acting efficacious drug to treat COVID-19 cases. It was … treating
adults with mild to moderate COVID-19 patients. Considering the importance of molnupiravir, …

Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2

WP Painter, W Holman, JA Bush… - Antimicrobial agents …, 2021 - Am Soc Microbiol
… In the ferret model of influenza, treatment of pandemic influenza A virus with molnupiravir
diseases, including COVID-19. The ability of molnupiravir to potentially treat highly pathogenic …

Computational analysis of molnupiravir

AV Sharov, TM Burkhanova, T Taskın Tok… - International journal of …, 2022 - mdpi.com
… with molnupiravir in humans to treat COVID-19 [2]. Initially, molnupiravir was developed for
the treatment … Nowadays, coronavirus is one of the most discussed and actively investigated …

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

CM Lieber, RM Cox, J Sourimant, JD Wolf… - Nature …, 2022 - nature.com
… VOC delta was excluded from transmission studies, since we had not detected any infectious
particles in nasal lavages of molnupiravir-treated animals at any time and nasal turbinates …