Innate immune deficiencies in patients with COVID-19

M Peyneau, V Granger, PH Wicky, D Khelifi-Touhami… - medRxiv, 2021 - medrxiv.org
… Our study reveals a marked dysregulation of innate immunity in COVID-19 patients, which
… and severity in COVID-19 patients. We found cellular and molecular features of myeloid cell …

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

L Ruhl, I Pink, JF Kühne, K Beushausen… - Signal transduction and …, 2021 - nature.com
… in the manifestation of life-threatening COVID-19 and in disease recovery are … dysregulation
of immune responses after SARS-CoV-2 infection. To define hallmarks of severe COVID-19

SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

H Chen, W Liu, Y Wang, D Liu, L Zhao, J Yu - EBioMedicine, 2021 - thelancet.com
… populations between COVID-19 patients and healthy controls, we found a dysregulated
immune … immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19. …

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

…, MGH COVID-19 Collection & Processing Team… - bioRxiv, 2020 - biorxiv.org
… These issues are highlighted by the current COVID-19 pandemic, wherein many clinical …
with severe COVID-19. We found that blood plasma from bacterial sepsis or COVID-19 patients …

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

…, Karolinska KI/K COVID-19 Study … - Proceedings of the …, 2021 - National Acad Sciences
… These findings suggest dysregulation of myeloid development in severe COVID-19, … Further
research is needed to understand if and how immature myeloid derived cells in COVID-19

Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

AF Rendeiro, J Casano, CK Vorkas… - Life science …, 2021 - life-science-alliance.org
COVID-19 patients and healthy donors with flow cytometry, we demonstrate that SARS-CoV-2
is associated with broad dysregulation … cells coupled to expansion of myeloid cells. Severe …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
… with COVID-19; in particular, we highlight the data that suggest that a dysregulated
innate … Increasing evidence indicates that the dysregulated myeloid response to SARS-CoV-2 …

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
… Together our findings suggest a myeloid-driven … system act as mediators of COVID-19 disease
severity. … some parallels, the dysregulated cytokine release in COVID-19 was shown here …

Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan

T Takano, T Matsumura, Y Adachi… - International …, 2021 - academic.oup.com
… by COVID-19 is greater than those in other regions including Japan. Thus, characteristics
of COVID-19-induced myeloid cell … Here, we analyzed cellular dynamics of myeloid-derived …

Innate immune deficiencies are associated with severity and poor prognosis in patients with COVID-19

M Peyneau, V Granger, PH Wicky, D Khelifi-Touhami… - Scientific reports, 2022 - nature.com
… and severity in COVID-19 patients. We found cellular and molecular features of myeloid cell
… of dysregulated inflammation. However, in both cases, our findings suggest that in severe …