NLRP3 inflammasome: a joint, potential therapeutic target in management of COVID-19 and fertility problems

M Bazrafkan, E Hosseini, M Nazari, CA Amorim… - Journal of Reproductive …, 2021 - Elsevier
… overcome COVID-19 long-term consequences, one possible approach is to control
inflammasomes … , inflammasome pathway activation is responsible for the damages caused, then …

Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19

A Saeedi-Boroujeni… - …, 2021 - Taylor & Francis
… role of NLRP3 inflammasomes in immunopathogenesis is now … , and NLRP3 inflammasome
hyperactivity in COVID-19, conducting … role of Tranilast in COVID-19 and also highlights the …

[HTML][HTML] Sex-related overactivation of NLRP3 inflammasome increases lethality of the male COVID-19 patients

H Zhang, Y Tang, J Tao - Frontiers in molecular biosciences, 2021 - frontiersin.org
… males and females may activate the NLRP3 inflammasome to varying degrees resulting in …
NLRP3 inflammasome activation and proposes the potential therapeutic targets for COVID-19

Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin

AÖ Şehirli, U Aksoy, RB Koca-Ünsal, S Sayıner - Medical hypotheses, 2021 - Elsevier
… of NLRP3 inflammasome. In light of these findings, we think that melatonin treatment during
COVID-19 … seen in periodontal tissues by preventing the activation of NLRP3 inflammasome. …

[HTML][HTML] Probiotics regulating inflammation via NLRP3 inflammasome modulation: a potential therapeutic approach for COVID-19

AN Kasti, KD Synodinou, IA Pyrousis, MD Nikolaki… - Microorganisms, 2021 - mdpi.com
… the impact PB have on stimulating the assembly of NLRP3 inflammasome, as well as the …
of PB in COVID-19. We assessed preclinical studies focusing on the activation of NLRP3 by PB …

Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells

S Sur, R Steele, TS Isbell, R Ray, RB Ray - Mbio, 2022 - Am Soc Microbiol
… exposure to the COVID-19 exosomes. Furthermore, COVID-19 exosomes significantly …
that exosomes from COVID-19 plasma trigger NLRP3 inflammasome in endothelial cells of …

Targeting of the NLRP3 Inflammasome for Early COVID-19

C Marchetti, K Mould, IW Tengesdal, WJ Janssen… - bioRxiv, 2021 - biorxiv.org
NLRP3 inflammasome aggregates has also been shown in the lungs of fatal COVID-19
pneumonia and in PBMCs and tissues of COVID… of the NLRP3 inflammasome in COVID-19 in …

Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19

YY Yong, L Zhang, YJ Hu, JM Wu, L Yan, YR Pan… - Clinical …, 2022 - Elsevier
… of COVID-19. Here, we discuss the autophagy regulation at different stages of COVID-19. …
of autophagy activators in COVID-19 by inhibiting the NLRP3 inflammasome, thereby avoiding …

Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation

A Paniri, H Akhavan-Niaki - Life sciences, 2020 - Elsevier
COVID-19-mediated inflammation responses. In this review, we describe the mechanism of
IL-6 and NLRP3 inflammasome in … in IL-6 and NLRP3 inflammasome activation. Finally, we …

Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment

A Bertoni, F Penco, H Mollica, P Bocca… - Journal of Allergy and …, 2022 - Elsevier
NLRP3 inflammasome in patients with COVID-19 but not in healthy subjects. We therefore
isolated peripheral blood monocyte from patients with COVID-19 … , inflammasome activation, …