Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway

B Khalil, NS Sharif-Askari, S Hafezi, FS Sharif-Askari… - Plos one, 2024 - journals.plos.org
… treated COVID-19 patients, the reduction in the levels of NLRP3 … of the NLRP3 inflammasome
pathway to COVID-19 severity … via downregulating the NLRP3 inflammasome pathway. …

Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment

A Bertoni, F Penco, H Mollica, P Bocca… - Journal of Allergy and …, 2022 - Elsevier
NLRP3 inflammasome in patients with COVID-19 but not in healthy subjects. We therefore
isolated peripheral blood monocyte from patients with COVID-19 … , inflammasome activation, …

[HTML][HTML] Pre-existing cytokine and NLRP3 inflammasome activation and increased vascular permeability in diabetes: a possible fatal link with worst COVID-19 …

V Lambadiari, F Kousathana, A Raptis… - Frontiers in …, 2020 - frontiersin.org
… So, we hypothesize that the pre-existing hyperactivation of NLRP3 inflammasome, …
contributing factors for the development of severe COVID-19 complications. Such patients could be …

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

P Pan, M Shen, Z Yu, W Ge, K Chen, M Tian… - Nature …, 2021 - nature.com
… through facilitating the NLRP3 inflammasome activation. We … NLRP3 inflammasome through
direct interaction with NLRP3 … that NLRP3 inflammasome is a potential target for COVID-19

Inflammasome activation at the crux of severe COVID-19

SM Vora, J Lieberman, H Wu - Nature Reviews Immunology, 2021 - nature.com
… indirect inflammasome activation and the critical role of inflammasomes in severe COVID-19. …
The NLRP3 inflammasome is known to be activated by highly pathogenic coronaviruses, …

Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome

O Paul, JQ Tao, E West, L Litzky, M Feldman… - Respiratory …, 2022 - Springer
… data show that NLRP3 inflammasome pathway activation was not different between COVID-19
and non-COVID-19 ARDS suggesting that this pathway is not COVID-19 specific and is …

… NLRP3 inflammasome in an animal model for Coronavirus Disease 2019 (COVID19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV …

CM Sergi, B Chiu - Journal of medical virology, 2021 - search.ebscohost.com
… of patients with COVID19.Although the inflammatory basis underlying COVID19 fatality …
1 we suggest that an animal model based on NLRP3 inflammasome may be helpful. We are …

… as a regulator of inflammation and NLRP3 inflammasome, the main fragments in the puzzle of immunopathogenesis of different inflammatory diseases and COVID-19

S Houshmandfar, A Saeedi-Boroujeni… - Naunyn-Schmiedeberg's …, 2021 - Springer
NLRP3 inflammasome hyperactivity is known as a mechanism that is involved in inflammation
and cytokine storm in COVID-19… with NLRP3 inflammasome is investigated and explained. …

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein

M Yalcinkaya, W Liu, MN Islam, AG Kotini… - Scientific reports, 2021 - nature.com
… Several studies have indicated that NLRP3 inflammasome activation may play a central role
… Markers of NLRP3 inflammasome activation correlate with severity of disease in Covid-19

[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology

E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao… - Nature, 2022 - nature.com
Inflammasome activation and the accompanying inflammatory response are … NLRP3
inflammasome pathway reverses chronic lung pathology. Notably, this blockade of inflammasome