Targeting inflammasome activation in COVID-19: delivery of RNA interference-based therapeutic molecules

L Gedefaw, S Ullah, TMH Lee, SP Yip, CL Huang - Biomedicines, 2021 - mdpi.com
… have died from COVID-19. In peripheral blood mononuclear cells, active NLRP3 inflammasome
was observed and was associated with disease severity in COVID-19 patients [3]. In …

Elevated markers of gut leakage and inflammasome activation in COVID19 patients with cardiac involvement

H Hoel, L Heggelund, DH Reikvam… - Journal of internal …, 2021 - Wiley Online Library
… priming of NLRP3 inflammasome through … NLRP3 inflammasome has also been proposed
to play a role in the pathogenesis COVID-19, but data on the role of these inflammasomes

[PDF][PDF] SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications

V Quagliariello, A Bonelli, A Caronna… - Eur. Rev. Med …, 2020 - europeanreview.org
… As insight is gained into the clinical phenotypes associated with COVID-19, we propose
NLRP3 as therapeutic target warranting rapid investigation in clinical trials highlighting car…

… fertility during COVID-19 infection: exploring potential pharmacological and natural therapeutic approaches for comorbidity, by focusing on NLRP3 inflammasome …

E Hosseini, HR Kohan-Ghadr, M Bazrafkan… - Journal of assisted …, 2023 - Springer
… 3 (NLRP3) inflammasome pathway activation is partly responsible for the inflicted damages
in both COVID-19 … is on NLRP3 inflammasome in the pathogenesis of COVID-19 infection …

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

M Zheng, EP Williams, RKS Malireddi, R Karki… - Journal of Biological …, 2020 - ASBMB
… the murine coronavirus mouse hepatitis virus (MHV) activated the NLRP3 inflammasome
and … Deleting NLRP3 inflammasome components or the downstream cell death executioner …

[HTML][HTML] Age-induced NLRP3 inflammasome over-activation increases lethality of SARS-CoV-2 pneumonia in elderly patients

PC Lara, D Macías-Verde, J Burgos-Burgos - Aging and disease, 2020 - ncbi.nlm.nih.gov
… This NLRP3 over-activated status in elderly individuals, is also … the NLRP3 inflammasome
plays a central role in the increased lethality observed in elderly patients infected by COVID-19

SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore

JW Guarnieri, A Angelin, DG Murdock… - Frontiers in …, 2023 - frontiersin.org
… from severe COVID-19 patients display increased NLRP3-I … COVID-19 patients have
increased levels of activated NLRP3-I … which SARS-CoV-2 activates the NLRP3-I is imperative for …

[HTML][HTML] Integrative considerations during the COVID-19 pandemic

L Alschuler, A Weil, R Horwitz, P Stamets… - Explore (New York …, 2020 - ncbi.nlm.nih.gov
… CXCL9 is a monokine, induced by interferon, which increases lymphocytic infiltration, 3
and which is implicated in NLRP3 inflammasome activation. Adequate sleep also ensures the …

[HTML][HTML] Clinical and biological data on the use of hydroxychloroquine against SARS‐CoV‐2 could support the role of the NLRP3 inflammasome in the pathogenesis …

A Lucchesi, P Silimbani, G Musuraca… - Journal of Medical …, 2021 - ncbi.nlm.nih.gov
… of an unbalanced NLRP3 inflammasome response to the … severe COVID19: in relatively
recent times, some authors have highlighted how the activation of the NLRP3 inflammasome is …

Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines

SJ Lee, R Channappanavar, TD Kanneganti - Trends in immunology, 2020 - cell.com
… -containing 3 (NLRP3) inflammasome activation is beneficial … that has caused the coronavirus
2019 (COVID-19) pandemic. … immune responses, inflammasome activation, inflammatory …