[HTML][HTML] Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
KL Siu, KS Yuen, C Castaño-Rodriguez, ZW Ye… - The FASEB …, 2019 - ncbi.nlm.nih.gov
… (19, 20). ORF3a expression in infected cells is relatively abundant, and anti-ORF3a is also
detectable in infected individuals (19). … for activation of the NLRP3 inflammasome. To our …
detectable in infected individuals (19). … for activation of the NLRP3 inflammasome. To our …
Ultramicronized palmitoylethanolamide inhibits NLRP3 inflammasome expression and pro-inflammatory response activated by SARS-CoV-2 spike protein in cultured …
… upregulation of inflammasome-dependent inflammatory pathways (NLRP3, Caspase-1) …
NLRP3 signalling pathway outlining a novel mechanism of action of this lipid against COVID-19…
NLRP3 signalling pathway outlining a novel mechanism of action of this lipid against COVID-19…
Do inflammasome impact COVID-19 severity?
MB Calado, CE da Silva Santana, S Crovella - Virusdisease, 2021 - Springer
… COVID-19 pandemic has proven to be a dramatic challenge, … major site of clinical
manifestations, COVID-19 has shown … response, and the NLRP3 inflammasome could be a …
manifestations, COVID-19 has shown … response, and the NLRP3 inflammasome could be a …
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity
G Bombaci, MA Sarangdhar, N Andina… - Life science …, 2022 - life-science-alliance.org
… To investigate the role of RNH1 in NLRP3 inflammasome activation, we generated RNH1-deficient
(RNH1-KO) THP1 cells using the CRISPR/cas9 system and stimulated them with …
(RNH1-KO) THP1 cells using the CRISPR/cas9 system and stimulated them with …
Inflammasome activation and pyroptosis in lymphopenic liver patients with COVID-19
A Kroemer, K Khan, M Plassmeyer… - Journal of …, 2020 - journal-of-hepatology.eu
… coronavirus viroporin 3a activates the NLRP3 inflammasome… critical role of the inflammasome
in COVID-19 have therapeutic … prevention of pyroptosis in COVID-19 may be beneficial. …
in COVID-19 have therapeutic … prevention of pyroptosis in COVID-19 may be beneficial. …
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19
SJ Theobald, A Simonis, T Georgomanolis… - EMBO Molecular …, 2021 - embopress.org
… Our study provides a rational for pharmacologically targeting the NLRP3 inflammasome
and associated cytokines in severe cases of COVID-19. Profound alteration of macrophage …
and associated cytokines in severe cases of COVID-19. Profound alteration of macrophage …
… and COVID-19 ischemic stroke recovery—evolving evidence for the mediating roles of the ACE2/angiotensin-(1–7)/mas receptor axis and NLRP3 inflammasome
CMN Che Mohd Nassir, MKI Zolkefley… - International journal of …, 2022 - mdpi.com
… -containing 3 (NLRP3) inflammasome, and nuclear factor … patients with or without COVID-19
intercurrent infection. This … axis and NLRP3 inflammasome in COVID-19-mediated AIS …
intercurrent infection. This … axis and NLRP3 inflammasome in COVID-19-mediated AIS …
[PDF][PDF] Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
… of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how
metformin inhibits inflammasome … We show that metformin inhibited NLRP3 inflammasome …
metformin inhibits inflammasome … We show that metformin inhibited NLRP3 inflammasome …
6-shogaol exhibits anti-viral and anti-inflammatory activity in covid-19-associated inflammation by regulating nlrp3 inflammasomes
… the AIM2/NLRP3 inflammasome pathway, we initially activated the inflammasome pathway
in … Then, the expression of AIM2/NLRP3 in the presence of these stimulants was checked by …
in … Then, the expression of AIM2/NLRP3 in the presence of these stimulants was checked by …
NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration
… consequences following the new coronavirus disease 19 (COVID-19) infection. Systemic
inflammation, through activation of the NLRP3 inflammasome, impairs immune homeostasis in …
inflammation, through activation of the NLRP3 inflammasome, impairs immune homeostasis in …