过去一年中添加的文章,按日期排序

Molnupiravir in Combination With Nirmatrelvir/Ritonavir: No Cause for Alarm

DR Kuritzkes - The Journal of Infectious Diseases, 2024 - academic.oup.com
2 天前 - … global response to the COVID-19 pandemic. To date, 3 small-molecule antiviral
drugs have been … [2], MOV remains an important option for certain patients because it is orally

[引用][C] Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses

W Zhao, CS Lupala, S Hou, S Yang, Z Yan… - Quantitative …, 2024 - Wiley Online Library
4 天前 - … severe acute respiratory syndrome coronavirus 2 (SARS‐… In contrast, oral clinical
drugs targeting viral protease and … and LTV exhibited comparable antiviral activity as NTV and …

Prevention of Post COVID-19 Condition by Early Treatment with Ensitrelvir in the Phase 3 SCORPIO-SR Trial

H Yotsuyanagi, N Ohmagari, Y Doi, M Yamato… - Antiviral Research, 2024 - Elsevier
4 天前 - coronavirus disease 2019 (COVID-19) condition (PCC). Patients with mild-to-moderate
COVID-19 … of symptom onset; received 5-day oral ensitrelvir 125 mg (375 mg on day 1), …

Molecular Interactions and Mechanisms of COVID-19 Inhibition 2.0

F Caruso, M Rossi - International Journal of Molecular Sciences, 2024 - mdpi.com
11 天前 - … cytokines for the antiviral response against epithelium-… A general overview of the
COVID-19 pandemic discussed … of Paxlovid, the first orally available COVID-19 drug [10]. The …

Pharmacokinetics, Mass Balance, Safety, and Tolerability of Obeldesivir in Healthy Participants

O Anoshchenko, M Abdelghany, A Lichtman… - Clinical Pharmacology … - Wiley Online Library
12 天前 - oral therapies for COVID-19 with low potential for drug–drug interactions.
Obeldesivir is an orally … The in vitro antiviral activities of nucleoside prodrugs remdesivir and …

In silico Screening of Potential Drug Candidate against Chain a of Coronavirus Binding Protein from Major Nigella Bioactive Compounds

MB Rahman, ABM Abdullah… - Asian Journal of …, 2024 - info.stmdigitallibrary.com
15 天前 - … Results: Four different antiviral agents that had been used in the treatment of
COVID-19 patients … It can be considered for inhalation and oral drug development. Generally, …

Computational Insights into SARS-CoV-2 Main Protease Mutations and Nirmatrelvir Efficacy: The Effects of P132H and P132H-A173V

YL Xia, WW Du, YP Li, Y Tao, ZB Zhang… - Journal of Chemical …, 2024 - ACS Publications
16 天前 - … Nirmatrelvir, a pivotal component of the oral antiviral Paxlovid for COVID-19,
targets the SARS-CoV-2 main protease (M pro ) as a covalent inhibitor. Here, we employed …

Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults

K Penrose, A Srivastava, Y Shen… - Infectious Diseases and …, 2024 - Springer
17 天前 - … for low utilization of COVID-19 oral antivirals during a period of … severe COVID-19
and determined whether perceived risk was associated with the use of COVID-19 oral antiviral

COVID-19 clinical rebound after treatment with nirmatrelvir/ritonavir

D Camp, M Caputo, FM Echevarria, CJ Achenbach - 2024 - researchsquare.com
19 天前 - … and effective oral antiviral therapeutic used for treatment of mild-to-moderate COVID-19.
… There is a lack of information on frequency of COVID-19 rebound after NM/r in routine …

Inclusion of racial and ethnic groups in clinical trials for COVID-19 and post-acute COVID-19 syndrome: an analysis of studies registered on ClinicalTrials. gov

A Chaka, D Pan, M Irshad, H Piranie… - Journal of …, 2024 - journalofinfection.com
20 天前 - … use of oral antiviral drugs and the risk of post covid-19 … to either COVID-19 or
post-acute COVID-19 syndrome (… 2023 when we searched for ‘COVID-19’. Trials with fewer than …