… pathology induced by SARS-CoV-2 in lung tissues was reduced in Nlrp3 −/− mice compared
to wild-type C57BL/6 mice. … thus COVID-19 like pathology in human ACE2 transgenic mice. …

… pathology and mortality in COVID-19 will validate animal models for severe COVID-19 …
PFU) which did not induce pathology in mice without transgene expression. The transgenic …

… mice provide a useful model for studying the pathological … mice might also show differences
in pathogenesis. Here we demonstrate the use of K18-hACE2 mice for studies of COVID-19 …

… pathology, with SARS-CoV-2 replication evident in pneumocytes, were similar to that reported
in severe cases of COVID-19. … and observed pathology bears resemblance to COVID-19. …

… plays a causal role in COVID-19-associated lung damage and deaths [4, 5]. … mouse model
of COVID-19, capable of inducing severe lung pathology in mice and resembling COVID-19 in …

… To further examine the role of STING in COVID-19-like disease in K18-hACE2 mice, we
used suspension mass cytometry analysis to identify and distinguish a panel of immune cell …

… mouse models for COVID-19 has been limited to genetically modified mice expressing hACE2
(transgenic mice … to express hACE2 or transduced mice containing adenovirus or adeno-…

… Severe COVID-19 is characterized by persistent lung inflammation, inflammatory … for
pathology in the SARS-CoV-2-infected MISTRG6-hACE2 humanized mouse model of COVID-19, …

… vascular pathology remains controversial. In this study, we used a set of new mouse genetic
… (23) to rigorously test endothelial contribution to COVID-19-associated vascular pathology. …

… by weight loss, severe pulmonary pathology, and high-titer … mice to study COVID-19
pathogenesis. Our strategy allows sensitization of all mouse strains and all genetically modified mice …