PI3Kδ inhibition as a potential therapeutic target in COVID-19

G Palma, T Pasqua, G Silvestri, C Rocca… - Frontiers in …, 2020 - frontiersin.org
… of death in COVID-19, this review aims to evaluate an alternative therapeutic strategy by
using the PI3Kδ inhibitor Idelalisib in association with Ebastine, which may successful inhibit the …

The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19

MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
… It has been suggested that the PI3Kδ inhibitor idelalisib, alone or in … COVID-19. Accordingly,
ebastine in association with an antiviral is being investigated for the treatment of COVID-19. …

PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy

S Fattahi, Z Khalifehzadeh-Esfahani… - Immunologic …, 2022 - Springer
… Using therapeutic methods that inhibit harmful immune responses … COVID-19 disease. We
highlighted the potential contribution of PI3K/Akt/mTOR inhibitors in the treatment of COVID-19

PI3K signaling in mechanisms and treatments of pulmonary fibrosis following sepsis and acute lung injury

JP Margaria, L Moretta, JC Alves-Filho, E Hirsch - Biomedicines, 2022 - mdpi.com
… These results suggests that COVID-19 disease severity is … inflammatory cytokines through
PI3K inhibition may prevent the … nemiralisib, an inhaled PI3Kδ-selective inhibitor that is under …

PI3KδInhibitor Duvelisib Modulates Inflammatory Profile in Severe COVID-19 Patients: Results from a Randomized Placebo-Controlled Phase 2 Study

H Zhang, S Wang, M Rupji, C Wu, S Chandrasekaran… - Blood, 2022 - ashpublications.org
… (PI3Kδ/γ) inhibitor for treating relapsed or refractory CLL/SLL and FL. PI3Kδinhibitors
promote the formation of a pool of T-cells with a memory phenotype by inhibiting aerobic …

D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis

F Yang, R Chen, W Li, H Zhu, X Chen, Z Hou… - Frontiers in …, 2021 - frontiersin.org
… time of the prevalence of coronavirus disease 2019 (COVID-19), … to PI3Kδ (A), PI3Kβ (B),
and NF-κB p65 (C). (D) 3D schematic diagram of active space binding of D-limonene and PI3Kδ

[PDF][PDF] PI3Kd Inhibition as a Potential Therapeutic Target in COVID-19

G Palma, T Pasqua, G Silvestri, C Rocca, P Gualtieri… - researchgate.net
… with an antiviral in the treatment of COVID-19 positive patients is underway (21). … COVID-19,
this review aims to evaluate an alternative therapeutic strategy by using the PI3Kd inhibitor

Inflammatory pathways in COVID19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
… In particular, PI3Kδ isoform inhibitors are considered as a valuable approach for the treatment
of inflammatory lung diseases. Therefore, PI3Kδ inhibitors idelalisib and ebastine, which …

Kinase inhibitors developed for treatment of hematologic malignancies: implications for immune modulation in COVID-19

CF Jacobs, E Eldering, AP Kater - Blood advances, 2021 - ashpublications.org
… in these cells to provide a rationale for how such inhibitors could modify clinical courses of
diseases, such as COVID-19. COVID-19 has major global impacts on health and economy, …

Discovery of highly selective and orally bioavailable PI3Kδ inhibitors with anti-inflammatory activity for treatment of acute lung injury

Y Tang, F Zheng, X Bao, Y Zheng, X Hu… - Journal of Medicinal …, 2023 - ACS Publications
… Although PI3Kδ inhibitors have been used in the treatment of … revealing the potential of PI3Kδ
inhibitors for the treatment of … promising therapeutic strategy for COVID-19-induced ARDS, …