PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19

MR Khezri - Human Cell, 2021 - Springer
… On the other hand, activation of the PI3K/AKT signaling pathway has been linked to the …
detected in patients with COVID-19 [5, 7]. Regarding the role of this pathway in inducing inflam…

The PI3K/Akt/mTOR pathway: a potential pharmacological target in COVID-19

MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
… of this pathway could ameliorate the course of SARS-CoV-2 infection. Single inhibitors of
PI3K, Akt, … In this review, we analyze the emerging role of the PI3K/Akt/mTOR axis in COVID-19

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients

R Abu-Eid, FJ Ward - Immunology letters, 2021 - Elsevier
… management of COVID-19 patients include … PI3K/Akt/mTOR pathway can address these
two goals and dissect how mitigating different components of the pathway can benefit COVID-19

The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy

MR Khezri, R Varzandeh… - Cellular & Molecular …, 2022 - Springer
… factors have been detected in samples from COVID-19 patients. Here we examine the
role of PI3K/AKT signaling pathways in regulation of these factors’ expression and activity. …

PI3K/Akt/mTOR pathway: a potential target for anti-SARS-CoV-2 therapy

S Fattahi, Z Khalifehzadeh-Esfahani… - Immunologic …, 2022 - Springer
… of PI3K/Akt/mTOR inhibitors in the treatment of COVID-19. … PI3K/Akt/mTOR pathway in
SARS-CoV-2 infection and to comment on the efficiency and effect of their inhibitors in COVID-19

D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis

F Yang, R Chen, W Li, H Zhu, X Chen, Z Hou… - Frontiers in …, 2021 - frontiersin.org
… of the prevalence of coronavirus disease 2019 (COVID-19), … Our study found that the PI3K/Akt
signaling pathway in the lung … AKT is the main effector kinase of the PI3K signaling pathway

Stochastic models for objects and images in oncology and virology: application to PI3K-Akt-mTOR signaling and COVID-19 disease

HH Barrett, L Caucci - Journal of Medical Imaging, 2021 - spiedigitallibrary.org
… mammalian target of rapamycin signaling pathway and to COVID-19 are discussed qualitatively.
… an unprecedented amount of molecular imaging data for an individual COVID patient. …

Is targeting Akt a viable option to treat advanced-stage COVID-19 patients?

PR Somanath - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
coronavirus disease-2019 (COVID-19) (25). The prolonged asymptomatic incubation period
in COVID-19 … However, a link between the Akt pathway and ACE2 activation in COVID-19

[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… -2 (SARS-CoV-2) infection-induced inflammatory responses are largely responsible for the
death of novel coronavirus disease 2019 (COVID-19) patients. However, the mechanism by …

COVID-19: immunohistochemical analysis of TGF-β signaling pathways in pulmonary fibrosis

CB Vaz de Paula, S Nagashima, V Liberalesso… - International journal of …, 2021 - mdpi.com
… biomarkers (ACE-2, AKT-1, Caveolin-1, … -β1 signaling pathways and pulmonary fibrosis.
The study consisted of 24 paraffin lung samples from patients who died of COVID-19 (COVID-19