Material basis and mechanism of Chansu injection for COVID19 treatment based on network pharmacology and molecular docking technology

Y Xu, W Peng, D Han, Z Wang, F Feng… - Evidence‐Based …, 2021 - Wiley Online Library
… The potential signaling pathway for COVID-19 treatment … (AT1R) activates this signaling
pathway, thereby regulating the … Therefore, the PI3K/Akt signaling pathway could regulate the …

[HTML][HTML] Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors

N Balmeh, S Mahmoudi, N Mohammadi… - Informatics in Medicine …, 2020 - Elsevier
… development and spread of the coronavirus disease 2019 (COVID-19). Therefore, … signaling
pathways. Second, the findings presented that this miRNA had a considerable role in PI3K/…

Antiviral drug screen of kinase inhibitors identifies cellular signaling pathways critical for SARS-CoV-2 replication

G Garcia Jr, A Sharma, A Ramaiah, C Sen, D Kohn… - BioRxiv, 2020 - biorxiv.org
… To identify antiviral compounds that could be used for COVID-19 treatment, we established
a SARS-CoV-2 infectious cell culture system and virological assays using Vero-E6 cells. …

Network pharmacology and bioinformatics analysis identifies potential therapeutic targets of Naringenin against COVID-19/LUSC

W Wu, X Jiao, W Song, P Wu, P Xiao… - Frontiers in …, 2023 - frontiersin.org
… Results: We discovered numerous COVID-19/LUSC target genes and examined their …
COVID-19. We intersected the therapeutic target genes of naringenin with the LUSC, COVID-19-…

Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis

D Mukhopadhyay, N AlSawaftah… - ACS Pharmacology & …, 2021 - ACS Publications
… The COVID-19 pandemic had a devastating impact on the health of millions of people and …
on TMPRSS2 and lung cancer progression pathways involving AKT/PI3K/mTOR/PTEN genes. …

[HTML][HTML] Diabetes and COVID-19: Role of insulin resistance as a risk factor for COVID-19 severity

C Gangadharan, R Ahluwalia… - World journal of …, 2021 - ncbi.nlm.nih.gov
… more susceptible to coronavirus disease 2019 (COVID-19), … between insulin resistance and
COVID-19 disease severity. … , which impairs insulin signaling pathways affecting metabolic …

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Z Amini-Farsani, M Yadollahi-Farsani, S Arab… - International …, 2021 - Elsevier
… This review will analyze the role of miRNAs in the regulation of immune response against
COVID-19 especially inflammatory pathway based on bioinformatics prediction. …

In silico analysis and preclinical findings uncover potential targets of anti-cervical carcinoma and COVID-19 in laminarin, a promising nutraceutical

J Liu, Y Chen, L Nie, X Liang, W Huang… - Frontiers in …, 2022 - frontiersin.org
… In the pathway analysis, we found that laminarin’s targets played a role in many cell signaling
pathways related to COVID-19 and cervical carcinoma. The VEGF signaling pathway plays …

Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology

F Liu, Y Li, Y Yang, M Li, Y Du, Y Zhang, J Wang… - Drug …, 2021 - Taylor & Francis
… with COVID-19; Furthermore, PI3K-Akt signaling pathway, NF-kappa B signaling pathway,
and p53 signaling pathway are also … PI3K-Akt mediated NF-kappa B is a classic inflammatory …

New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts

B Wang, D Li, A Fiselier, I Kovalchuk… - Cell death …, 2022 - nature.com
… We also looked at the effect on signaling pathways. Western blotting showed that CBD
decreased the levels of both phosphorylated p65 (p-p65, Ser536) and phosphorylated AKT1/2/3 (…