The complex combination of COVID-19 and diabetes: pleiotropic changes in glucose metabolism

A Mahrooz, G Muscogiuri, R Buzzetti, E Maddaloni - Endocrine, 2021 - Springer
… So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, …
-term consequences and pleiotropic alterations in glucose metabolism following COVID-19 and …

Possible Pleiotropic Effect of SRY Gene May Increase Male Susceptibility to COVID-19

VGO Evangelho, ML Bello, HC Castro… - American Journal of …, 2021 - academic.oup.com
… cardiovascular disease and COVID-19 severity. Besides being … Intriguingly, hormonal changes
in adult men may result from … with hypertension and severity of COVID 19: interaction with …

[HTML][HTML] PNPLA3 and COVID19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system

CJ Pirola, S Sookoian - Liver International, 2021 - ncbi.nlm.nih.gov
… Epigenetic investigations based on the rs738409 can also be of help at identification of
factors that may affect COVID19 outcomes, including not only changes in cells of the immune …

Revisiting pleiotropic effects of type I interferons: rationale for its prophylactic and therapeutic use against SARS-CoV-2

D Garcia-del-Barco, D Risco-Acevedo… - Frontiers in …, 2021 - frontiersin.org
… We expect that this review will help scientists and clinicians on the Covid-19 battlefield to …
Typically, conformational changes in the intracellular portion of the receptor lead to the …

The benefits of heparin use in COVID-19: pleiotropic antiviral activity beyond anticoagulant and anti-inflammatory properties

G Lippi, BM Henry, EJ Favaloro - Seminars in Thrombosis and …, 2023 - thieme-connect.com
Coronavirus disease 2019 (COVID-19), a life-threatening infectious disease caused by severe
acute respiratory syndrome coronavirus 2 (… now suggest that COVID-19 is a prothrombotic …

[HTML][HTML] The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants

E Sahin, A Dag, F Eren - Hepatology Forum, 2024 - ncbi.nlm.nih.gov
… as COVID-19, it might change the prognosis of the main infectious disease. Having chronic
liver diseases (CLDs), in particular, cirrhosis, worsen the situation of patients in terms of …

Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection Outcomes

J Chung, V Vig, X Sun, X Han, GT O'Connor… - Journal of Clinical …, 2022 - mdpi.com
change (FC) = 1.02; p = 0.067}, as well as in the peak COVID… genetic correlation of AMD and
COVID-19 and attempted to identify … (ie, pleiotropy analysis). The relevance of AMD risk and …

Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19

D Liu, J Yang, B Feng, W Lu, C Zhao, L Li - Journal of Infection, 2021 - Elsevier
… probes tagging IFNAR2 showing pleiotropic association with hospitalized COVID-19 in blood.
… the changes in gene expression in patients with COVID-19 in comparison with the control. …

[HTML][HTML] Adiponectin: A pleiotropic hormone with multifaceted roles

SS Shklyaev, GA Melnichenko… - Проблемы …, 2021 - cyberleninka.ru
… , driven mainly by changes in the … COVID-19 negative and COVID-19 positive patients
was found. On the contrary, in another study investigating a role of adipose tissue in COVID-19

Elevated levels of pleiotropic interleukin-6 (IL-6) and interleukin-10 (IL-10) are critically involved with the severity and mortality of COVID-19: An updated longitudinal …

S Jafrin, MA Aziz, MS Islam - Biomarker Insights, 2022 - journals.sagepub.com
coronavirus disease (COVID-19) prevalence was first commenced in 2019 by a highly variating
virus “SARS-CoV-2” (severe acute respiratory syndrome coronavirus … against COVID-19, …