Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID19 disease

MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
cytokine storms which poses severe respiratory conditions in coronavirus disease-19 (COVID-19).
Host … the patients' susceptibility and COVID-19 severity and pathophysiology. Gene …

[HTML][HTML] COVID-19: immunopathology and its implications for therapy

X Cao - Nature reviews immunology, 2020 - nature.com
… However, two studies, based on the analysis of 222 and 173 patients with COVID-19, …
severe COVID-19 exhibit substantially elevated serum levels of pro-inflammatory cytokines

[PDF][PDF] Cytokines as predictors of COVID-19 severity: evidence from a meta-analysis

Ł Szarpak, B Nowak, D Kosior, A Zaczynski… - Pol Arch Intern …, 2021 - researchgate.net
… in the concentration of IL6 and other proinflammatory cytokines also affects the central nervous
… To confirm the cytokine's effect as a predictor of the severity of COVID-19, we performed a …

[HTML][HTML] A glimpse into the eye of the COVID-19 cytokine storm

K Kuppalli, AL Rasmussen - EBioMedicine, 2020 - thelancet.com
… that severe COVID-19 is associated with significant increases in pro-inflammatory cytokines
… The degree of lymphopenia and a proinflammatory cytokine storm is higher in severe COVID

[PDF][PDF] Kinins and cytokines in COVID-19: a comprehensive pathophysiological approach

F van de Veerdonk, MG Netea, M van Deuren… - 2020 - pdfs.semanticscholar.org
… cell influx and proinflammatory cytokines leading to damage. In … receptors is an important
feature of COVID-19, resulting in a very high … effect on disease caused by COVID-19. This kinin-…

Deciphering the COVID19 cytokine storm: systematic review and meta‐analysis

R Mulchandani, T Lyngdoh… - European journal of …, 2021 - Wiley Online Library
… between circulating cytokine levels and COVID-19, and more … severity among clinically
confirmed patients of COVID-19. … a pro-inflammatory cytokine storm is higher in severe COVID-…

[HTML][HTML] Elevated interleukin-10 levels in COVID-19: potentiation of pro-inflammatory responses or impaired anti-inflammatory action?

H Islam, TC Chamberlain, AL Mui, JP Little - Frontiers in Immunology, 2021 - frontiersin.org
… of the coronavirus disease 2019 (COVID-19; caused by the SARS-CoV-2 virus) is the
overproduction of pro-inflammatory cytokines arising from excessive immune cell activation (ie, …

COVID-19 coagulopathy, thrombosis, and bleeding

NC Chan, JI Weitz - Blood, The Journal of the American Society …, 2020 - ashpublications.org
… a cytokine storm mediated by proinflammatory cytokines such … Proinflammatory cytokines
and SARS-CoV-2 infection of the … in hospitalized patients with COVID-19 are potent triggers of …

[HTML][HTML] Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients

C Gao, L Zhu, CC Jin, YX Tong, AT Xiao, S Zhang - Clinical Immunology, 2020 - Elsevier
… monitoring proinflammatory cytokines in selected COVID-19 patients … for COVID-19 patients
with prolonged viral shedding. We also monitored the dynamics of proinflammatory cytokines

The cytokine storm and COVID19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… Anakinra, an IL-1 receptor antagonist that blocks the activity of proinflammatory cytokines
IL-1α and IL-1β, has been reported to improve the respiratory function and increase the …