[HTML][HTML] The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
… ARDS, and there is growing evidence that it reduces the inflammatory cell-mediated lung
injury by inhibiting neutrophil activation and subsequent pro-inflammatory cytokines. It also …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
… Cellular infection and viral replication cause activation of the inflammasome in the host
cell, leading to the release of proinflammatory cytokines and cell death by pyroptosis with …

An inflammatory cytokine signature helps predict COVID-19 severity and death

DMD Valle, S Kim-Schulze, HH Huang, N Beckmann… - medRxiv, 2020 - medrxiv.org
… damage in COVID-19 patients 14 . IL-1 is also a highly active pro-inflammatory cytokine and
… IL-8 is a potent proinflammatory cytokine playing a key role in the recruitment and activation …

[HTML][HTML] Proinflammatory IgG Fc structures in patients with severe COVID-19

S Chakraborty, J Gonzalez, K Edwards… - Nature …, 2021 - nature.com
… FcγRIIIa is present on monocytes, macrophages and NK cells in healthy adults and can
enhance cell activation, proinflammatory cytokine production and cytotoxic effector cell activity 18…

[HTML][HTML] Basic predictive risk factors for cytokine storms in COVID-19 patients

SG Shcherbak, AY Anisenkova, SV Mosenko… - Frontiers in …, 2021 - frontiersin.org
… Objective: A critical role in coronavirus disease 2019 (COVID-19… of proinflammatory cytokines,
known as “a cytokine storm” (CS), … for CS development in COVID-19 patients and integrate …

[HTML][HTML] A deep look into COVID-19 severity through dynamic changes in blood cytokine levels

DA Kleymenov, EN Bykonia, LI Popova… - Frontiers in …, 2021 - frontiersin.org
… of cytokines associated with different severities of COVID-19, and levels of some cytokines
… Our results show significantly higher levels of proinflammatory cytokines (TNF-α and IL-6) …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
… ) from seven COVID-19 cases and six healthy controls, peripheral monocytes and lymphocytes
were not found to express substantial amounts of pro-inflammatory cytokines, suggesting …

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, CC Bortolasci, BK Puri, W Marx, A O'Neil… - Cytokine, 2021 - Elsevier
… Importantly, this pattern of immune dysregulation is progressive and levels of proinflammatory
cytokines and chemokines increase dramatically with illness severity and may be some ten…

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
COVID-19 patients. Hence, this review highlights the activation, signal transduction and
cross-talk of NF-κB with regard to cytokine storm in COVID-19. … these pro-inflammatory cytokines

[HTML][HTML] Cytokine overproduction and immune system dysregulation in alloHSCT and COVID-19 patients

A Lange, J Lange, E Jaskuła - Frontiers in Immunology, 2021 - frontiersin.org
… of pro-inflammatory cytokines dysregulates the cytokine … Chronic production of pro-inflammatory
cytokines advances along … In COVID-19 patients pro-inflammatory cytokine production …