Clinical trials for the prevention and treatment of COVID19: current state of play

JS Davis, D Ferreira, JT Denholm… - Medical Journal of …, 2020 - Wiley Online Library
… review summarises currently registered large clinical trials of therapeutic agents for COVID-19.
Prophylaxis trials We found 12 trials assessing prophylactic agents for COVID-19 (Box 2). …

COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
… Under Research Exclusion (SECURE-IBD) helped to identify the ineffectiveness of
hydroxychloroquine as a prophylactic therapy for infection with SARS-CoV2 (110) and the potential …

Hydroxychloroquine or chloroquine for treatment or prophylaxis of COVID-19: a living systematic review

AV Hernandez, YM Roman, V Pasupuleti… - Annals of internal …, 2020 - acpjournals.org
… or chloroquine for prophylaxis against COVID-19. In RCTs and … with hydroxychloroquine to
treat COVID-19 were often conflicting… therapy for the treatment of coronavirus disease 2019 (…

A critical analysis of the use of cilgavimab plus tixagevimab monoclonal antibody cocktail (Evusheld™) for COVID-19 prophylaxis and treatment

D Focosi, A Casadevall - Viruses, 2022 - mdpi.com
… In designing mAb therapies for prophylaxis, a major goal is … a mAb used for the prophylaxis
of respiratory syncytial virus which … Prophylactic administration of the Evusheld™ cocktail was …

… vs standard-dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID-19 …

S Mazloomzadeh, S Khaleghparast, B Ghadrdoost… - Jama, 2021 - jamanetwork.com
… anticoagulation (first hypothesis) and statin therapy vs matching placebo (second … COVID-19,
intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic

[HTML][HTML] Comparison of safety and efficacy between therapeutic or intermediate versus prophylactic anticoagulation for thrombosis in COVID-19 patients: a systematic …

HJ Lee, HJ Jang, WI Choi, J Joh, J Kim… - … and Critical care, 2023 - synapse.koreamed.org
… with COVID-19 given an anticoagulant as a therapeutic or intermediate dose and those given
a prophylactic … In two previous RCTs [18,19], the incidence of thrombosis in the therapeutic

[HTML][HTML] Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID19: a multi‐center, open‐label, randomized controlled trial

US Perepu, I Chambers, A Wahab, P Ten Eyck… - Journal of Thrombosis …, 2021 - Elsevier
… Therefore, additional studies are needed to confirm our findings and assess the impact of
anticoagulation therapy on the long‐term effects of COVID19. Several other trials …

COVID-19: Ophthalmic prophylactic and therapeutic measures

S Waikar, A Oli - Indian Journal of Ophthalmology, 2020 - journals.lww.com
… the prophylaxis and treatment of COVID-19-related disease. In a small study on patients
with COVID-19 … [ 7 ] This drug may also have therapeutic potential for use in COVID-19-related …

COVID-19 infection: viral macro-and micro-vascular coagulopathy and thromboembolism/prophylactic and therapeutic management

AS Manolis, TA Manolis, AA Manolis… - Journal of …, 2021 - journals.sagepub.com
Coronavirus-2019 (COVID-19) predisposes patients to … The prevalence of venous
thromboembolism in COVID-19 patients … seems more specific for COVID-19 and is associated with …

Coronavirus disease-2019 (COVID-19): an updated review

M Rudrapal, SJ Khairnar, LB Borse… - Drug research, 2020 - thieme-connect.com
… To envisage possible therapeutic/ prophylactic strategies for COVID-19, it is inevitable to
comprehensively understand the background of the diseases process with thorough insight into …