[HTML][HTML] Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

A Cortegiani, M Ippolito, M Greco, V Granone, A Protti… - Pulmonology, 2021 - Elsevier
… of severe COVID-19. The aim of this systematic review was to describe the rationale for the
use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence

Antithrombotic therapy in patients with COVID-19?-Rationale and Evidence

C Godino, A Scotti, N Maugeri, N Mancini… - International journal of …, 2021 - Elsevier
… with better outcomes in moderate and severe COVID-19 patients with signs of … COVID-19
severity. We provide a practical approach on antithrombotic therapy management for COVID-19

Potential effects of vaccinations on the prevention of COVID-19: rationale, clinical evidence, risks, and public health considerations

J Sultana, G Mazzaglia, N Luxi… - Expert review of …, 2020 - Taylor & Francis
… and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis
vaccines in the context of COVID-19 as well as to provide an overview on the COVID-19-…

Potential role of anti-interleukin (IL)-6 drugs in the treatment of COVID-19: rationale, clinical evidence and risks

S Crisafulli, V Isgrò, L La Corte, F Atzeni, G Trifiro - BioDrugs, 2020 - Springer
… In this review, the pathogenesis of COVID-19 as a rationale for anti-IL-6 use will … evidence
of potential benefits, safety monitoring, and ongoing experimental clinical studies in COVID-19

Janus kinase inhibitors and coronavirus disease (COVID)-19: rationale, clinical evidence and safety issues

M Gatti, E Turrini, E Raschi, P Sestili, C Fimognari - Pharmaceuticals, 2021 - mdpi.com
… In order to provide a general picture of the current safety profile of JAK inhibitors in COVID-19,
we used the COVID-19 EUA section of the FAERS public dashboard to extract AEs of …

Rationale for azithromycin in COVID-19: an overview of existing evidence

I Gyselinck, W Janssens… - BMJ Open …, 2021 - bmjopenrespres.bmj.com
… of COVID-19, despite the lack of high-quality evidence. In this … of azithromycin for treating
COVID-19. Interest in azithromycin … Currently, in vivo reports on azithromycin in COVID-19 are …

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

FMP Van Haren, C Page, JG Laffey, A Artigas… - Critical Care, 2020 - Springer
… In this focused review, we present the biological and scientific rationale for the use of nebulised
UFH for COVID-19 pneumonia and ARDS in hospitalised patients and make a call for an …

Rationale for targeting complement in COVID19

A Polycarpou, M Howard, CA Farrar… - EMBO molecular …, 2020 - embopress.org
… We have collected evidence from all the current studies we are aware of on SARS-CoV-2 …
-1 and MERS-CoV infection linking severe COVID-19 disease directly with dysfunction of the …

Acute kidney injury associated with COVID19—Cumulative evidence and rationale supporting against direct kidney injury (infection)

MS Parmar - Nephrology, 2021 - Wiley Online Library
… ~15% 26 of patients with severe COVID-19, so lesser exposure of the … evidence of lack of
direct infection. In summary, at present, the cumulative evidence suggests that AKI in COVID-19

[HTML][HTML] Rationale and criteria for a COVID-19 model framework

…, G Ippolito, COVID-19 Scoping Review Working Group - Viruses, 2021 - ncbi.nlm.nih.gov
COVID-19 based on current literature evidence. The model was set up by identifying the
molecular pathophysiology related to the COVID-19 … a multiomics approach to COVID-19. This …