Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
… this is closely related to the cytokine release syndrome (CRS)… and cytokine release occurring
in COVID-19 cases is variable… modulators for the treatment of COVID-19, but the urgency of …

Cytokine release syndrome in severe COVID-19

JB Moore, CH June - Science, 2020 - science.org
… Compared to the monoclonal antibodies, tocilizumab, sarilumab, and siltuxizumab,
bazedoxifene has additional advantages related to possible effectiveness against COVID-19 entry …

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
… role of IL-6 in COVID-19, we propose to repurpose tocilizumab to treat severe cases of
COVID-19. … Infection is a common adverse effect associated with immunomodulators such as …

The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease

R Pasrija, M Naime - International Immunopharmacology, 2021 - Elsevier
associated with seriousness of the infection in critical cases [7]. Hypertensive patients are
prone to develop the severe COVID-19 … to be a risk factor in fatal COVID-19 infections as well. …

[HTML][HTML] Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome

P Du, J Geng, F Wang, X Chen, Z Huang… - International journal of …, 2021 - ncbi.nlm.nih.gov
… the IL-6 response in patients with COVID-19, clarified the pathogenesis of the role of IL-6-mediated
CRS in severe COVID-19, and highlighted the rationale for the use of anti-IL-6 agents …

Use of tocilizumab for COVID-19-induced cytokine release syndrome: a cautionary case report

J Radbel, N Narayanan, PJ Bhatt - Chest, 2020 - Elsevier
… Tocilizumab is theorized to treat the CRS that can occur in patients with COVID-19, similar
to its use in CRS secondary to chimeric antigen receptor T-cell therapy. Thus far, reports …

Cytokine release syndrome‐associated encephalopathy in patients with COVID19

P Perrin, N Collongues, S Baloglu… - European Journal of …, 2021 - Wiley Online Library
… -associated neurological disturbances in COVID-19 expand previous observations showing
that hyperinflammation is associated with … Cytokine release syndrome is a potentially fatal …

The cytokine storm and COVID19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… a cytokine storm is associated with COVID-19 severity and is also a crucial cause of death
from COVID-19cytokine secretion patterns based on COVID-19 severity are shown in Table 2. …

Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department

T Waltuch, P Gill, LE Zinns, R Whitney… - The American Journal of …, 2020 - Elsevier
… Below, we describe four similar COVID-19 serology positive, RT-PCR negative patients
who presented to our New York City Pediatric Emergency Department (PED) approximately 1 …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
… that cytokine storms play an important role in severe COVID-19 cases. Therefore, neutralising
key inflammatory factors in cytokine release … The combination of IL-6 and cell-related IL-6R …